4.7 Article

The CRBN, CUL4A and DDB1 Expression Predicts the Response to Immunomodulatory Drugs and Survival of Multiple Myeloma Patients

Related references

Note: Only part of the references are listed.
Article Hematology

Multiple cereblon genetic changes are associated with acquired resistance to lenalidomide or pomalidomide in multiple myeloma

Sarah Gooding et al.

Summary: The study found that in patients with myeloma, as the exposure to IMiD drugs increased, the frequency of CRBN abnormalities also increased gradually, with almost one-third of patients having CRBN alterations by the time they were refractory to pomalidomide (POM). These CRBN abnormalities were associated with inferior outcomes to POM in patients already refractory to lenalidomide (LEN).

BLOOD (2021)

Article Oncology

CUL4A regulates endometrial cancer cell proliferation, invasion and migration by interacting with CSN6

Xiangrong Wang et al.

Summary: The study found that CUL4A was highly expressed in endometrial cancer cells, and knockdown of CUL4A significantly inhibited cell proliferation, invasion, and migration. However, overexpression of CSN6 alleviated the effects of CUL4A knockdown on the cells.

MOLECULAR MEDICINE REPORTS (2021)

Article Oncology

Exploiting DNA repair defects in triple negative breast cancer to improve cell killing

Kevin J. Lee et al.

THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY (2020)

Article Oncology

Cancer statistics, 2019

Rebecca L. Siegel et al.

CA-A CANCER JOURNAL FOR CLINICIANS (2019)

Article Medicine, General & Internal

Multiple myeloma

Shaji K. Kumar et al.

NATURE REVIEWS DISEASE PRIMERS (2017)

Review Oncology

Immunomodulatory Drugs (IMiDs) in Multiple Myeloma

Shahzad Raza et al.

CURRENT CANCER DRUG TARGETS (2017)

Article Oncology

The clinical significance of cereblon expression in multiple myeloma

Steven R. Schuster et al.

LEUKEMIA RESEARCH (2014)

Article Multidisciplinary Sciences

Lenalidomide Causes Selective Degradation of IKZF1 and IKZF3 in Multiple Myeloma Cells

Jan Kroenke et al.

SCIENCE (2014)

Article Genetics & Heredity

Oncogenic CUL4A determines the response to thalidomide treatment in prostate cancer

Shancheng Ren et al.

JOURNAL OF MOLECULAR MEDICINE-JMM (2012)

Article Biochemistry & Molecular Biology

The Molecular Basis of CRL4DDB2/CSA Ubiquitin Ligase Architecture, Targeting, and Activation

Eric S. Fischer et al.

Article Multidisciplinary Sciences

Identification of a Primary Target of Thalidomide Teratogenicity

Takumi Ito et al.

SCIENCE (2010)

Article Immunology

Ikaros controls isotype selection during immunoglobulin class switch recombination

MacLean Sellars et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2009)