Journal
JOURNAL OF CLINICAL MEDICINE
Volume 10, Issue 16, Pages -Publisher
MDPI
DOI: 10.3390/jcm10163694
Keywords
acupuncture; chemotherapy; peripheral neuropathy; breast cancer; Semmes-Weinstein monofilament; neuropathic pain
Categories
Funding
- An Nan Hospital, China Medical University in Tainan, Taiwan [ANHRF106-02]
- China Medical University Hospital, Taichung, Taiwan [DMR-109-160, DMR-108-BC-8]
- Chinese Medicine Research Center of China Medical University under the Featured Areas Research Center Program
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The study evaluated the effect of manual acupuncture on chemotherapy-induced peripheral neuropathy in breast cancer patients. Results showed that acupuncture can alleviate neuropathic pain and improve touch perception thresholds, with the verum acupuncture group showing more improvement in touch perception thresholds and lower pain severity compared to the sham acupuncture group.
Chemotherapy-induced peripheral neuropathy (CIPN) is a disabling side effect caused by neurotoxic chemotherapy. This randomized controlled trial aimed to evaluate the effect of manual acupuncture on CIPN. Twenty eligible breast cancer patients receiving taxane chemotherapy treatment were recruited and randomly divided into verum acupuncture and sham acupuncture groups. Each group received 15 treatments over 9 weeks. Quantitative tactile detection thresholds were measured using Semmes-Weinstein monofilament testing (SWM). The World Health Organization Quality of Life scale (WHOQOL-BREF), the Functional Assessment of Cancer Therapy/Gynecologic Oncology Group-Neurotoxicity (FACT/GOG-Ntx), and the Brief Pain Inventory-Short Form (BPI-SF) were measured before and after treatment. The between-group comparison of SWM revealed that the verum acupuncture group had more improvement of touch perception thresholds compared to the sham acupuncture group. The average pain severity in the BPI-SF of the verum acupuncture group was significantly lower than that of the sham acupuncture group. There were no significant differences in the FACT/GOG-Ntx trial outcome index and WHOQOL-BREF scores between the acupuncture and sham groups. The results suggest that acupuncture can alleviate the neuropathic pain of CIPN and improve touch perception thresholds.
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