4.7 Review

Combination Therapy for Neuropathic Pain: A Review of Recent Evidence

Related references

Note: Only part of the references are listed.
Article Health Care Sciences & Services

Combination therapy with methadone and duloxetine for cancer-related pain: a retrospective study

Zachary A. Curry et al.

Summary: The combination therapy of duloxetine and methadone reduces cancer-related pain and emotional symptom burden compared to either medication as a single agent. 28% of patients reported at least a two-point reduction in pain scores. Most study participants reported cancer pain with neuropathic components, and high adherence rates were observed in patients with follow-up appointments.

ANNALS OF PALLIATIVE MEDICINE (2021)

Review Anesthesiology

Nabiximols in Chronic Neuropathic Pain: A Meta-Analysis of Randomized Placebo-Controlled Trials

Igor Dykukha et al.

Summary: The pooled analysis of nine RCTs demonstrated that nabiximols was superior to placebo in reducing chronic neuropathic pain with a small effect size. Larger RCTs are needed to further evaluate the efficacy of nabiximols in neuropathic pain.

PAIN MEDICINE (2021)

Article Medicine, Research & Experimental

The effect of a topical combination of clonidine and pentoxifylline on post-traumatic neuropathic pain patients: study protocol for a randomized, double-blind placebo-controlled trial

Oli Abate Fulas et al.

Summary: This study protocol focuses on a randomized, double-blind, placebo-controlled, phase II clinical trial investigating the topical use of clonidine and pentoxifylline in combination for post-traumatic peripheral neuropathic pain. The primary outcome measures include intensity of spontaneous pain and mechanical allodynia, while secondary outcome measures include pain relief scores and changes in punctate hyperalgesia area. The trial aims to provide evidence for the efficacy and safety of this formulation in alleviating neuropathic pain, potentially opening doors for further investigations into tissue oxygenation-enhancing agents in topical treatments for neuropathic pain.

TRIALS (2021)

Article Oncology

The combined analgesic effect of pregabalin and morphine in the treatment of pancreatic cancer pain, a retrospective study

Junzhu Dai et al.

Summary: The study showed that combining pregabalin with morphine for pancreatic cancer pain management resulted in similar analgesic efficacy compared to using morphine alone, but with a significant lower dose of morphine in the combination group. Functional interference scores also differed significantly between the two groups.

CANCER MEDICINE (2021)

Article Neurosciences

Pharmacological treatment of central neuropathic pain: consensus of the Brazilian Academy of Neurology

Rogerio Adas Ayres de Oliveira et al.

ARQUIVOS DE NEURO-PSIQUIATRIA (2020)

Review Anesthesiology

A Comprehensive Algorithm for Management of Neuropathic Pain

Daniel Bates et al.

PAIN MEDICINE (2019)

Article Medicine, General & Internal

RoB 2: a revised tool for assessing risk of bias in randomised trials

Jonathan A. C. Sterne et al.

BMJ-BRITISH MEDICAL JOURNAL (2019)

Article Neurosciences

THC and gabapentin interactions in a mouse neuropathic pain model

Nicholas Atwal et al.

NEUROPHARMACOLOGY (2019)

Article Pharmacology & Pharmacy

A pharmacokinetic drug-drug interaction study between pregabalin and tramadol in healthy volunteers

Soyoung Lee et al.

EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY (2018)

Article Pharmacology & Pharmacy

Synergism between gabapentin-tramadol in experimental diabetic neuropathic pain

Hugo F. Miranda et al.

FUNDAMENTAL & CLINICAL PHARMACOLOGY (2018)

Article Medicine, Research & Experimental

Morphine and pregabalin in the treatment of neuropathic pain

Yue Wang et al.

EXPERIMENTAL AND THERAPEUTIC MEDICINE (2017)

Article Clinical Neurology

Combination treatment of neuropathic pain: Danish expert recommendations based on a Delphi process

Jakob Vormstrup Holbech et al.

JOURNAL OF PAIN RESEARCH (2017)

Article Medicine, General & Internal

Neuropathic pain

Luana Colloca et al.

NATURE REVIEWS DISEASE PRIMERS (2017)

Article Oncology

Efficacy and safety of pregabalin in patients with neuropathic cancer pain undergoing morphine therapy

Zhi Dou et al.

ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY (2017)

Review Clinical Neurology

Topical Treatments for Localized Neuropathic Pain

Roberto Casale et al.

CURRENT PAIN AND HEADACHE REPORTS (2017)

Article Pharmacology & Pharmacy

Antinociceptive Interaction of Tramadol with Gabapentin in Experimental Mononeuropathic Pain

Hugo F. Miranda et al.

BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY (2016)

Article Pharmacology & Pharmacy

Opioid and cannabinoid synergy in a mouse neuropathic pain model

Nicholas P. Kazantzis et al.

BRITISH JOURNAL OF PHARMACOLOGY (2016)

Article Medicine, General & Internal

The Pharmacological Therapy of Chronic Neuropathic Pain

Andreas Binder et al.

DEUTSCHES ARZTEBLATT INTERNATIONAL (2016)

Article Chemistry, Medicinal

The Antinociceptive Effects of Tramadol and/or Gabapentin on Rat Neuropathic Pain Induced by a Chronic Constriction Injury

Janette Nallely Corona-Ramos et al.

DRUG DEVELOPMENT RESEARCH (2016)

Article Geriatrics & Gerontology

An Algorithm for Neuropathic Pain Management in Older People

Gisele Pickering et al.

DRUGS & AGING (2016)

Review Clinical Neurology

Neuropathic Pain

Janne Gierthmuehlen et al.

SEMINARS IN NEUROLOGY (2016)

Article Clinical Neurology

Pharmacotherapy for neuropathic pain in adults: a systematic review and meta-analysis

Nanna B. Finnerup et al.

LANCET NEUROLOGY (2015)

Review Medicine, General & Internal

Single dose oral analgesics for acute postoperative pain in adults - an overview of Cochrane reviews

R. Andrew Moore et al.

COCHRANE DATABASE OF SYSTEMATIC REVIEWS (2015)

Article Pharmacology & Pharmacy

Add-On Treatment with Pregabalin for Patients with Uncontrolled Neuropathic Pain Who Have Been Referred to Pain Clinics

Jose-Luis de la Calle et al.

CLINICAL DRUG INVESTIGATION (2014)

Review Clinical Neurology

Drug Combinations in the Treatment of Neuropathic Pain

Elon Eisenberg et al.

CURRENT PAIN AND HEADACHE REPORTS (2014)

Article Clinical Neurology

Factors predicting adverse events associated with pregabalin administered for neuropathic pain relief

Yuko Kanbayashi et al.

PAIN RESEARCH & MANAGEMENT (2014)

Review Anesthesiology

Challenges in design and interpretation of chronic pain trials

R. A. Moore et al.

BRITISH JOURNAL OF ANAESTHESIA (2013)

Review Clinical Neurology

Combination pharmacotherapy for management of chronic pain: from bench to bedside

Ian Gilron et al.

LANCET NEUROLOGY (2013)

Article Anesthesiology

Combined carbamazepine and pregabalin therapy in a rat model of neuropathic pain

T. S. Hahm et al.

BRITISH JOURNAL OF ANAESTHESIA (2012)

Article Clinical Neurology

The impact of chronic pain-European patients' perspective over 12 months

Tony O'Brien et al.

SCANDINAVIAN JOURNAL OF PAIN (2012)

Article Endocrinology & Metabolism

Painful diabetic peripheral neuropathy: consensus recommendations on diagnosis, assessment and management

S. Tesfaye et al.

DIABETES-METABOLISM RESEARCH AND REVIEWS (2011)

Article Clinical Neurology

Evidence-based guideline: Treatment of painful diabetic neuropathy

V. Bril et al.

NEUROLOGY (2011)

Article Clinical Neurology

EFNS guidelines on neuropathic pain assessment: revised 2009

G. Cruccu et al.

EUROPEAN JOURNAL OF NEUROLOGY (2010)