4.7 Article

RNA-Protein Interaction Analysis of SARS-CoV-2 5′ and 3′ Untranslated Regions Reveals a Role of Lysosome-Associated Membrane Protein-2a during Viral Infection

Related references

Note: Only part of the references are listed.
Article Biochemistry & Molecular Biology

Identification of Required Host Factors for SARS-CoV-2 Infection in Human Cells

Zharko Daniloski et al.

Summary: Researchers conducted a genome-scale CRISPR screen to identify host factors crucial for SARS-CoV-2 infection, highlighting genes related to ATPase proton pump, Retromer, and Commander complexes. Validating these gene targets through multiple methods, they found shared transcriptional changes in cholesterol biosynthesis when top-ranked genes were lost. Loss of RAB7A was shown to reduce viral entry by sequestering the ACE2 receptor inside cells, underscoring its importance early in the viral infection process.
Article Biochemistry & Molecular Biology

Genome-wide CRISPR Screens Reveal Host Factors Critical for SARS-CoV-2 Infection

Jin Wei et al.

Summary: Identification of essential host genes for SARS-CoV-2 infection, including ACE2 and Cathepsin L, and the discovery of pro-viral genes and pathways specific to SARS lineage and pan-coronavirus provide potential therapeutic targets and insights into pathogenesis of COVID-19. Small-molecule antagonists of these gene products inhibited SARS-CoV-2 infection across species, highlighting their conserved role in susceptibility to highly pathogenic CoVs.
Review Microbiology

Characteristics of SARS-CoV-2 and COVID-19

Ben Hu et al.

Summary: This review summarizes the research progress on SARS-CoV-2 and COVID-19, including virology characteristics, pathogenesis, and recent advances in treatment methods. Furthermore, it discusses in detail the potential wildlife hosts and zoonotic origin of this emerging virus.

NATURE REVIEWS MICROBIOLOGY (2021)

Article Biochemistry & Molecular Biology

Secondary structure of the SARS-CoV-2 5'-UTR

Zhichao Miao et al.

Summary: The 5'UTR of SARS-CoV-2 contains stable structures, including a very stable four-way junction close to the AUG start codon. Sequence alignment analysis of SARS-CoV-2 variants' 5'UTRs revealed a highly conserved structure with few co-variations, confirming the secondary structure model based on probing experiments.

RNA BIOLOGY (2021)

Article Biochemistry & Molecular Biology

Integration of the Drug-Gene Interaction Database (DGIdb 4.0) with open crowdsource efforts

Sharon L. Freshour et al.

Summary: The Drug-Gene Interaction Database (DGIdb) is a web resource that provides information on drug-gene interactions and druggable genes. DGIdb 4.0 is the latest major version release, featuring integration with crowdsourced efforts, addition of new sources, and updates to the data.

NUCLEIC ACIDS RESEARCH (2021)

Article Microbiology

The SARS-CoV-2 RNA-protein interactome in infected human cells

Nora Schmidt et al.

Summary: Characterizing the interactions between SARS-CoV-2 viral RNAs and host cell proteins during infection can enhance our understanding of viral RNA functions and the host innate immune response. Identification of specific host proteins that restrict viral replication and exploring defense strategies will aid in the development of targeted therapeutics against SARS-CoV-2.

NATURE MICROBIOLOGY (2021)

Article Biochemistry & Molecular Biology

Discovery and functional interrogation of SARS-CoV-2 RNA-host protein interactions

Ryan A. Flynn et al.

Summary: The study identified host proteins that bind to SARS-CoV-2 RNA and protect the host from virus-induced cell death. It also found a physical and functional connection between SARS-CoV-2 and mitochondria, highlighting the organelle as a general platform for antiviral activity.
Editorial Material Pharmacology & Pharmacy

In Vitro and Animal Models for SARS-CoV-2 research

Kazuo Takayama

TRENDS IN PHARMACOLOGICAL SCIENCES (2020)

Review Microbiology

Novel human coronavirus (SARS-CoV-2): A lesson from animal coronaviruses

Nicola Decaro et al.

VETERINARY MICROBIOLOGY (2020)

Article Multidisciplinary Sciences

A SARS-CoV-2 protein interaction map reveals targets for drug repurposing

David E. Gordon et al.

NATURE (2020)

Review Cell Biology

Canonical and Noncanonical Autophagy as Potential Targets for COVID-19

Melissa Bello-Perez et al.

CELLS (2020)

Article Immunology

Gargle lavage as a viable alternative to swab for detection of SARS-CoV-2

Ankit Mittal et al.

INDIAN JOURNAL OF MEDICAL RESEARCH (2020)

Review Microbiology

Human Coronavirus: Host-Pathogen Interaction

To Sing Fung et al.

ANNUAL REVIEW OF MICROBIOLOGY, VOL 73 (2019)

Article Biochemistry & Molecular Biology

Hepatitis C virus infection increases autophagosome stability by suppressing lysosomal fusion through an Arl8b-dependent mechanism

Kellyann N. Jones-Jamtgaard et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2019)

Article Biochemical Research Methods

RNA-protein interaction detection in living cells

Muthukumar Ramanathan et al.

NATURE METHODS (2018)

Review Clinical Neurology

Danon disease: a phenotypic expression of LAMP-2 deficiency

Yukari Endo et al.

ACTA NEUROPATHOLOGICA (2015)

Article Biochemistry & Molecular Biology

RNautophagy/DNautophagy possesses selectivity for RNA/DNA substrates

Katsunori Hase et al.

NUCLEIC ACIDS RESEARCH (2015)

Article Virology

Continuous and Discontinuous RNA Synthesis in Coronaviruses

Isabel Sola et al.

ANNUAL REVIEW OF VIROLOGY, VOL 2 (2015)

Article Biochemistry & Molecular Biology

DrugBank 4.0: shedding new light on drug metabolism

Vivian Law et al.

NUCLEIC ACIDS RESEARCH (2014)

Letter Cell Biology

Discovery of a novel type of autophagy targeting RNA

Yuuki Fujiwara et al.

AUTOPHAGY (2013)

Review Biochemistry & Molecular Biology

The biological regulation of ABCE1

Ye Tian et al.

IUBMB LIFE (2012)

Review Biochemistry & Molecular Biology

Regulation of stress granules in virus systems

James P. White et al.

TRENDS IN MICROBIOLOGY (2012)

Review Immunology

Molecular biology and replication of hepatitis E virus

Dianjun Cao et al.

EMERGING MICROBES & INFECTIONS (2012)

Review Biochemistry & Molecular Biology

RNA-RNA and RNA-protein interactions in coronavirus replication and transcription

Isabel Sola et al.

RNA BIOLOGY (2011)

Article Urology & Nephrology

Mitochondrial Autophagy Promotes Cellular Injury in Nephropathic Cystinosis

Poonam Sansanwal et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2010)

Editorial Material Biochemical Research Methods

Posterior error probabilities and false discovery rates: Two sides of the same coin

Lukas Kaell et al.

JOURNAL OF PROTEOME RESEARCH (2008)

Article Biochemical Research Methods

Integration of biological networks and gene expression data using Cytoscape

Melissa S. Cline et al.

NATURE PROTOCOLS (2007)

Article Biochemistry & Molecular Biology

DrugBank: a comprehensive resource for in silico drug discovery and exploration

David S. Wishart et al.

NUCLEIC ACIDS RESEARCH (2006)

Article Multidisciplinary Sciences

Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles

A Subramanian et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)

Article Biochemistry & Molecular Biology

Mfold web server for nucleic acid folding and hybridization prediction

M Zuker

NUCLEIC ACIDS RESEARCH (2003)

Article Biochemistry & Molecular Biology

Molecular characterization of a novel intracellular hyaluronan-binding protein

L Huang et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2000)