Related references
Note: Only part of the references are listed.Vertical Pathway Inhibition Overcomes Adaptive Feedback Resistance to KRASG12C Inhibition
Meagan B. Ryan et al.
CLINICAL CANCER RESEARCH (2020)
The KRAS(G12C) Inhibitor MRTX849 Provides Insight toward Therapeutic Susceptibility of KRAS-Mutant Cancers in Mouse Models and Patients
Jill Hallin et al.
CANCER DISCOVERY (2020)
Selective apoptosis-inducing activity of synthetic hydrocarbon-stapled SOS1 helix with D-amino acids in H358 cancer cells expressing attoklor KRASG12C
Li-li Xu et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2020)
Targeting Krasg12c-mutant cancer with a mutation-specific inhibitor
J. G. Christensen et al.
JOURNAL OF INTERNAL MEDICINE (2020)
A H-REV107 Peptide Inhibits Tumor Growth and Interacts Directly with Oncogenic KRAS Mutants
Chang Woo Han et al.
CANCERS (2020)
KRAS: From undruggable to a druggable Cancer Target
Dipesh Uprety et al.
CANCER TREATMENT REVIEWS (2020)
GTP-State-Selective Cyclic Peptide Ligands of K-Ras(G12D) Block Its Interaction with Raf
Ziyang Zhang et al.
ACS CENTRAL SCIENCE (2020)
Small-Molecule Inhibitors Directly Targeting KRAS as Anticancer Therapeutics
Hao Chen et al.
JOURNAL OF MEDICINAL CHEMISTRY (2020)
Inhibition of K-Ras4B-plasma membrane association with a membrane microdomain-targeting peptide
Fang-Yi Li et al.
CHEMICAL SCIENCE (2020)
Discovery of potent SOS1 inhibitors that block RAS activation via disruption of the RAS-SOS1 interaction
Roman C. Hillig et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)
The Function of RAS Mutation in Cancer and Advances in its Drug Research
Shijie Chen et al.
CURRENT PHARMACEUTICAL DESIGN (2019)
Monosaccharide Analogues of Anticancer Peptide R-Lycosin-I: Role of Monosaccharide Conjugation in Complexation and the Potential of Lung Cancer Targeting and Therapy
Peng Zhang et al.
JOURNAL OF MEDICINAL CHEMISTRY (2019)
Impaired dendritic cell functions in lung cancer: a review of recent advances and future perspectives
Jing-Bo Wang et al.
CANCER COMMUNICATIONS (2019)
Octreotide, 40 years later
Steven W. J. Lamberts et al.
EUROPEAN JOURNAL OF ENDOCRINOLOGY (2019)
Enhancing the Cell Permeability of Stapled Peptides with a Cyclic Cell-Penetrating Peptide
Patrick G. Dougherty et al.
JOURNAL OF MEDICINAL CHEMISTRY (2019)
A Chemical-Intervention Strategy To Circumvent Peptide Hydrolysis by D-Stereoselective Peptidases
Samantha J. Bann et al.
JOURNAL OF MEDICINAL CHEMISTRY (2019)
Stapled Peptides-A Useful Improvement for Peptide-Based Drugs
Mattia Moiola et al.
MOLECULES (2019)
Targeting KRAS Mutant Cancers with a Covalent G12C-Specific Inhibitor
Matthew R. Janes et al.
CELL (2018)
Assessing Therapeutic Efficacy of MEK Inhibition in a KRASG12C-Driven Mouse Model of Lung Cancer
Shuai Li et al.
CLINICAL CANCER RESEARCH (2018)
Trypanothione reductase inhibition and anti-leishmanial activity of all-hydrocarbon stapled α-helical peptides with improved proteolytic stability
Marta Ruiz-Santaquiteria et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2018)
Iterative optimization yields Mcl-1-targeting stapled peptides with selective cytotoxicity to Mcl-1-dependent cancer cells
Raheleh Rezaei Araghi et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)
Precedence and Promise of Covalent Inhibitors of EGFR and KRAS for Patients with Non-Small-Cell Lung Cancer
Hengmiao Cheng et al.
ACS MEDICINAL CHEMISTRY LETTERS (2018)
Structural and functional characterization of a DARPin which inhibits Ras nucleotide exchange
Sandrine Guillard et al.
NATURE COMMUNICATIONS (2017)
Honokiol Induces Apoptosis, G1 Arrest, and Autophagy in KRAS Mutant Lung Cancer Cells
Lian-Xiang Luo et al.
FRONTIERS IN PHARMACOLOGY (2017)
A critical assessment of the synthesis and biological activity of p53/human double minute 2-stapled peptide inhibitors
Rike Wallbrecher et al.
BRITISH JOURNAL OF PHARMACOLOGY (2017)
A New Methodology for Incorporating Chiral Linkers into Stapled Peptides
Juan C. Serrano et al.
CHEMBIOCHEM (2017)
Discovery of a Direct Ras Inhibitor by Screening a Combinatorial Library of Cell-Permeable Bicyclic Peptides
Thi B. Trinh et al.
ACS COMBINATORIAL SCIENCE (2016)
Stapled peptide design: principles and roles of computation
Yaw Sing Tan et al.
DRUG DISCOVERY TODAY (2016)
Inhibition of Ral GTPases Using a Stapled Peptide Approach
Jemima C. Thomas et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2016)
MEK and TAK1 Regulate Apoptosis in Colon Cancer Cells with KRAS-Dependent Activation of Proinflammatory Signaling
Kelsey L. McNew et al.
MOLECULAR CANCER RESEARCH (2016)
Inhibition of Ras Signaling by Blocking Ras-Effector Interactions with Cyclic Peptides
Punit Upadhyaya et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2015)
Direct inhibition of oncogenic KRAS by hydrocarbon-stapled SOS1 helices
Elizaveta S. Leshchiner et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)
Targeted Therapies in Non-Small Cell Lung Cance-rBeyond EGFR and ALK
Sacha I. Rothschild
CANCERS (2015)
Synthesis, enzymatic stability and in vitro cytostatic effect of Daunorubicin-GnRH-III derivative dimers
Verena Natalie Schreier et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2013)
Design of Cell-Permeable Stapled Peptides as HIV-1 Integrase Inhibitors
Ya-Qiu Long et al.
JOURNAL OF MEDICINAL CHEMISTRY (2013)
Inhibition of Ras-effector interactions by cyclic peptides
Xianghong Wu et al.
MEDCHEMCOMM (2013)
Enzymatic Stability and Immunoregulatory Efficacy of a Synthetic Indolicidin Analogue with Regular Enantiomeric Sequence
Ching-Yun Chang et al.
ACS MEDICINAL CHEMISTRY LETTERS (2013)
A Comprehensive Survey of Ras Mutations in Cancer
Ian A. Prior et al.
CANCER RESEARCH (2012)
Global Cancer Statistics
Ahmedin Jemal et al.
CA-A CANCER JOURNAL FOR CLINICIANS (2011)
Assessing Helical Protein Interfaces for Inhibitor Design
Brooke N. Bullock et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2011)
An orthosteric inhibitor of the Ras-Sos interaction
Anupam Patgiri et al.
NATURE CHEMICAL BIOLOGY (2011)
Synthesis of all-hydrocarbon stapled α-helical peptides by ring-closing olefin metathesis
Young-Woo Kim et al.
NATURE PROTOCOLS (2011)
Targeting the protein prenyltransferases efficiently reduces tumor development in mice with K-RAS-induced lung cancer
Meng Liu et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
Hydrocarbon double-stapling remedies the proteolytic instability of a lengthy peptide therapeutic
Gregory H. Bird et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
GEFs and GAPs: Critical elements in the control of small G proteins
Johannes L. Bos et al.
CELL (2007)
Targeted elimination of prostate cancer by genetically directed human T lymphocytes
TPF Gade et al.
CANCER RESEARCH (2005)
Formation and characterization of a single Trp-Trp cross-link in indolicidin that confers protease stability without altering antimicrobial activity
K Ösapay et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)