Four novel HLA class II alleles identified using next-generation sequencing

We describe here four novel HLA class II alleles, DPA1*01:33, DPB1*1082:01, DPB1*1144:01, and DQA1*01:45, identified in our laboratory following the implementation of next generation sequencing (NGS) for routine high resolution HLA typing of donors and recipients for solid organ transplant and hematopoetic stem cell transplant. The NGS technology has improved our ability to match at all clinically HLA loci and to facilitate the interpretation of allele specific antibody and eplet matching.

Automated summary

This article describes four novel HLA class II alleles identified in our laboratory through the implementation of next generation sequencing, improving our ability to match at all clinically relevant HLA loci and facilitating the interpretation of allele specific antibody and eplet matching.