Journal
CHEMISTRYSELECT
Volume 6, Issue 35, Pages 9415-9420Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/slct.202102228
Keywords
Click chemistry; Cross-coupling; CuAAC; Imidazo[1; 2-a]pyridine; One-pot synthesis
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An efficient one-pot regioselective synthesis of 2-(1,2,3-triazolyl)methyl-3-alkynyl imidazo[1,2-a]pyridines is reported, yielding new imidazo[1,2-a]pyridines embedded with 4-substituted-[1,2,3]-triazole in good to excellent yields under mild reaction conditions via a one-pot sequence involving SN reaction with azide, copper-catalyzed [3+2] cycloaddition, and Sonogashira coupling reaction.
An efficient one-pot regioselective synthesis of 2-(1,2,3-triazolyl)methyl-3-alkynyl imidazo[1,2-a]pyridines is reported under simple and mild reaction conditions. The new imidazo[1,2-a]pyridines embedded with 4-substituted-[1,2,3]-triazole were obtained in good to excellent yields from 2-(chloromethyl)-3-iodo imidazo[1,2-a]pyridines via a one-pot sequence involving an SN reaction with azide, followed by copper-catalyzed [3+2]cycloaddition and a Sonogashira coupling reaction.
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