Journal
ARCHIVES OF ENDOCRINOLOGY METABOLISM
Volume 65, Issue 3, Pages 352-367Publisher
SBEM-SOC BRASIL ENDOCRINOLOGIA & METABOLOGIA
DOI: 10.20945/2359-3997000000376
Keywords
Potassium iodide; cognition; child; pregnant woman
Categories
Funding
- Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (Capes) Brasil [001]
- National Council for Scientific and Technological Development (CNPq) [408295/2017-1]
- Foundation for Support and Research of the State of Minas Gerais (Fapemig) [APQ03336-18]
- CNPq
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The study found that iodine supplementation during gestation in iodine-deficient areas can improve specific aspects of children's neurodevelopment, especially in gross motor skills. However, improvements in mental and behavioral development were not significant, requiring further research.
Objective:To investigate the effect of iodine supplementation during gestation on the neurocognitive development of children in areas where iodine deficiency is common. Materials and methods: Based on the PRISMA methodology, we conducted the search for articles in the PubMed, LILACS and Scopus databases, between March and April 2020, without limitation of dates. We used descriptors in English, Portuguese, and Spanish, without filters. Four clinical trials and four cohort articles were included in the review. Results: The maximum supplementation was 300 mu g of potassium iodide per day. The Bayley scale and Children's Communication Checklist-Short were used to assess neurodevelopment in children. There was no significant improvement in the children's mental development index and behavioural development index in the supplemented group; however, the psychomotor development index (PDI) showed improvement in the poorer gross motor skills. We found differences in the response time to sound in the supplemented group living in mild deficiency areas. Conclusion: Daily supplementation with iodine can improve poor psychomotor development of children living in mild to moderate iodine deficiency areas. Thus, it is necessary to perform further studies to assess the effect of supplementation on neurodevelopment before, during and after gestation in mild to moderate iodine deficiency areas.
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