Cystic artery velocity as a predictor of acute cholecystitis

Purpose To evaluate angle-corrected peak systolic cystic artery velocity (CAv) as a predictor of acute cholecystitis among patients presenting to the emergency department (ED) with right upper quadrant (RUQ) pain. Methods In this IRB-approved and retrospective study, CAv was evaluated in 73 patients, 43 who underwent definitive treatment with cholecystectomy or percutaneous cholecystostomy and 30 control patients without clinical suspicion for cholecystitis. In addition to CAv, the following were reviewed by 3 radiologists: CBD diameter, cholelithiasis, impacted stone in the neck, sludge, gallbladder wall thickness > 3 mm, gallbladder transverse dimension >= 4 cm, longitudinal dimension >= 8 cm, tensile gallbladder fundus sign, pericholecystic fluid, pericholecystic echogenic fat, and sonographic Murphy sign. Results Of the 43 patients who underwent definitive treatment, 25 had acute cholecystitis (34%) and 18 (25%) had chronic cholecystitis. Average CAv measurements were 50 +/- 16 cm/s (acute), 28 +/- 8 cm/s (chronic), and 22 +/- 8 cm/s (control; p < 0.0001). In univariate analysis, among patients who underwent definitive therapy, CAv >= 40 cm/s, gallbladder wall thickness, stone impaction, GB long dimension >= 8 cm, and elevated WBC were associated with acute cholecystitis (p < 0.05). In multivariate analysis, CAv >= 40 cm/s was the only statistically significant variable (p = 0.016). CAv >= 40 cm/s alone had a PPV of 94.7% and overall accuracy of 81.4% in diagnosing acute cholecystitis. Conclusion CAv >= 40 cm/s is highly associated with acute cholecystitis in patients presenting to the ED with RUQ pain.

Automated summary

Evaluation of angle-corrected peak systolic cystic artery velocity (CAv) as a predictor of acute cholecystitis found that CAv >= 40 cm/s is highly associated with acute cholecystitis and has a high positive predictive value and overall accuracy when used as a sole indicator.