A glassy carbon electrode modified based on molybdenum disulfide for determination of folic acid in the real samples

In the present study, the electrochemical behavior of Folic acid (FA) on the glassy carbon electrode modified with 2D-MoS2 nanosheets has been investigated utilizing differential pulse voltammetry (DPV), cyclic voltammetry (CV), and chronoamperometric techniques at pH 6.0 Britton-Robinson buffer. The experimental conditions, including the pH, scan rate, were optimized. Under the optimized experimental conditions, to determine the selectivity and sensitivity of FA, the DPV procedure was conducted in the linear dynamic range from 0.06 to 1.16 to 1.16-24.3 mu M with a detection limit of 32.0 nM. The 2D-MoS2 nanoparticle was synthesized and characterized by EDX and SEM methods. The proposed modified electrode offered an outstanding electrocatalytic activity towards the oxidation of FA. The FA detection successfully validated the analytical reliability of 2D-MoS2/GCE in the food samples with acceptable recoveries at the range of 97.1 and 103.1%. Based on the results, it can be speculated that 2D-MoS2/GCE can be used as an alternative analytical instrument to determine FA in real samples.

Automated summary

The electrochemical behavior of Folic acid on the glassy carbon electrode modified with 2D-MoS2 nanosheets was investigated in this study. The modified electrode showed outstanding electrocatalytic activity for the oxidation of FA, and successfully validated the analytical reliability of 2D-MoS2/GCE in food samples. The results suggest that 2D-MoS2/GCE can be an alternative analytical instrument for determining FA in real samples.