Bioactive CaTiO3 film prepared on the biomedical porous Ti-15Mo alloy by one-step hydrothermal treatment

The bioactive CaTiO3 film was grown on the surface of the microwave sintered porous Ti-15Mo alloy by one-step hydrothermal process in supersaturated Ca(OH)(2) solution. The microstructures of the film and apatite-forming ability and cytocompatibility of the hydrothermally treated porous Ti-15Mo alloy were then investigated. The results show that the hydrothermally treated sample has a thickness of approximately 250 nm and is mainly composed of CaTiO3 phase with some -OH groups except the alpha-Ti and beta-Ti phases. The porous structure of the Ti-15Mo alloy has no significant change after hydrothermal treatment. When immersed in SBF solution, the hydroxyapatite preferentially nucleates and grows on the inner surface and the pore sites, forming a layer of the calcium-deficient apatite on the surface of the hydrothermally treated porous Ti-15Mo alloy finally. The hydrothermal treatment is demonstrated to facilitate the proliferation of MG-63 cells over the porous Ti-15Mo alloy surface (p < 0.01), and promote the alloy from Grade 1 of non-toxic material to Grade 0. (C) 2021 The Author(s). Published by Elsevier B.V.

Automated summary

A bioactive CaTiO3 film was successfully grown on the surface of microwave-sintered porous Ti-15Mo alloy through hydrothermal treatment, promoting hydroxyapatite formation and enhancing cytocompatibility.