The Relationship Between Inflammation and Post-traumatic Stress Disorder

Background: Stress disorders, such as post-traumatic stress disorder (PTSD), are attracting much attention. However, the relationship between traumatic stress and inflammation is rarely discussed. Subjects and Methods: As studies have linked PTSD to altered susceptibility to various diseases, such a psychiatric condition may lead to long-term systematic changes in physiological functions. We searched PubMed with the keywords traumatic stress, stress disorders, post-traumatic stress disorder, and inflammation. Results: Based on 65 previously published studies, we reviewed the long-term effects of PTSD, as well as traumatic events, on inflammatory function from both epidemiological and biological perspectives. Post-traumatic stress disorder is related to the immune response, including an increase in inflammatory factors and a reduction in anti-inflammatory factors. Additionally, it has been demonstrated that traumatic stress disorder and immune disease share a common genetic basis at the gene expression level. Conclusions: Understanding this relationship is of great significance for optimizing treatment plans for patients with PTSD.

Automated summary

The relationship between PTSD and inflammation has been explored, showing that PTSD is related to immune response changes such as increased inflammatory factors and decreased anti-inflammatory factors. Studies have also indicated a common genetic basis at the gene expression level between traumatic stress disorder and immune diseases.