Journal
FRONTIERS IN PSYCHIATRY
Volume 12, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fpsyt.2021.713671
Keywords
aerobic exercise; mild cognitive impairment; RCTs; systematic review; meta-analysis
Categories
Funding
- Graduate Students Innovation Program of Chongqing [CYS21086]
- Fundamental Research Funds for the Central Universities of Southwest University [SWU1709240]
- Medical Research Program Project of Chongqing Municipal Health and Family Planning Commission [2015ZDXM034]
- Fundamental Research Funds for the Central Universities of Tongji University [22120180511]
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Regular aerobic exercise significantly improves cognitive function in older adults with MCI, as indicated by improvements in MMSE and MoCA scores. However, caution should be exercised when interpreting these findings due to the limitations of the study.
This study aimed to evaluate the effectiveness of aerobic exercise as a cognitive intervention for older adults with mild cognitive impairment (MCI). The PubMed, EMBASE (Ovid), Cochrane Library, Web of Science, and Medline databases were searched from their inception until 30 April 2021. Randomized controlled trials (RCTs) examining the effects of aerobic exercise on global cognitive function in older adults with MCI were included. Ten eligible trials with acceptable methodological quality were identified. The meta-analysis results showed that aerobic exercise significantly improved the MMSE (N = 956, MD = 0.60, 95% CI: 0.28-0.92, p = 0.0003, I-2 = 31%, fixed effects model) and MoCA scores (N = 398, MD = 1.67, 95% CI. 1.18-2.15, p < 0.0001, I-2 = 37%, fixed-effects model) and overall cognitive performance in patients with MCI. The results of this study suggest that participation in regular aerobic exercise can improve cognitive function in older adults with MCI. These findings should be used with caution considering the limitations of the study.
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