Journal
FRONTIERS IN ENDOCRINOLOGY
Volume 12, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fendo.2021.611512
Keywords
mathematical modeling; type 1 diabetes mellitus; islet transplantation; insulin secretion; insulin sensitivity; minimal model; C-peptide model
Categories
Funding
- St Vincent's Hospital Melbourne
- St Vincent's Pathology, University of Melbourne
- Department of Endocrinology and Diabetes
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The authors discuss modifications made to glucose challenge protocols and mathematical models in order to estimate insulin secretion, insulin sensitivity, and glucose effectiveness in patients with Insulin-Requiring Diabetes and those who received Pancreatic Islet Transplants for Type I diabetes. The evolution of protocols and models for use in Type I Diabetes and Insulin-Requiring Type 2 Diabetes that were the basis for studies in Islet Recipients is outlined. The ongoing application of adaptations is helping to clarify Islet pathophysiology in Islet Transplant Recipients.
The authors' perspective is described regarding modifications made in their clinic to glucose challenge protocols and mathematical models in order to estimate insulin secretion, insulin sensitivity and glucose effectiveness in patients living with Insulin-Requiring Diabetes and patients who received Pancreatic Islet Transplants to treat Type I diabetes (T1D) with Impaired Awareness of Hypoglycemia. The evolutions are described of protocols and models for use in T1D, and Insulin-Requiring Type 2 Diabetes (T2D) that were the basis for studies in the Islet Recipients. In each group, the need for modifications, and how the protocols and models were adapted is discussed. How the ongoing application of the adaptations is clarifying the Islet pathophysiology in the Islet Transplant Recipients is outlined.
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