Journal
FRONTIERS IN ENDOCRINOLOGY
Volume 12, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fendo.2021.675581
Keywords
polycystic ovary syndrome; mitochondrial DNA deletion; mitochondrial DNA copy number; mitochondria; infertility
Categories
Funding
- National Natural Science Foundation of China [81871136, 81501231, 81971344, 81771638]
- National Key Research and Development Program of China [2016YFC0905103]
- International Peace Maternity and Child Health Hospital Clinical Research Project [GFY5817, GFY5818]
- Shanghai Municipal Key Clinical Specialty
- Youth Science and Technology Innovation Studio, Shanghai Jiao Tong University School of Medicine
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The study found a strong association between mtDNA(4977) DR and PCOS, suggesting that it may represent an independent risk factor for PCOS. Further research is needed to explore the potential value of mtDNA as a biomarker for PCOS.
Background Polycystic ovary syndrome (PCOS) is a common endocrine disorder worldwide. We aimed to examine the associations of two mitochondrial DNA (mtDNA) biomarkers in the peripheral blood, mtDNA copy number (CN), and mtDNA(4977) deletion rate (DR), with PCOS in a clinical setting. Methods We performed a study involving 263 women with PCOS and 326 age-matched controls between June 2015 and June 2019. The mtDNA CN and mtDNA(4977) DR were measured using multiplex probe-based qPCR. The associations of the mtDNA CN and mtDNA(4977) DR with the risk of PCOS were estimated using logistic regression. Results Analysis of the associations between mtDNA biomarkers and PCOS indicate that the mtDNA CN (P = 0.003) and mtDNA(4977) DR (P < 0.001) in PCOS patients were significantly higher than those in the controls. After adjusting for the body mass index, luteinizing hormone/follicle-stimulating hormone ratio, and testosterone level, only higher mtDNA(4977) DR was associated with PCOS (odds ratio 1.053, 95% confidence interval 1.024 to 1.083; P < 0.001). The linear dose-response trends of the mtDNA(4977) DR were also supported by the quartile analysis. Conclusion Multivariable models suggest that mtDNA(4977) DR levels are strongly associated with PCOS and represent an independent risk factor for PCOS. Further investigation of the utility of mtDNA as a biomarker for PCOS is warranted.
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