Journal
FRONTIERS IN ENDOCRINOLOGY
Volume 12, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fendo.2021.676133
Keywords
letrozole; ovulation induction (OI); frozen-thawed embryo transfer; fertility preservation; endometrium preparation
Categories
Funding
- People's Livelihood Science and Technology Project of Hebei Province [20377714D]
- Natural Science Foundation of Hebei Province [H2019206707, H2019206674]
- National key Research and Development program [2018YFC1002104]
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Letrozole, as an aromatase inhibitor, has been widely used in infertility treatments, with its efficacy and safety confirmed by accumulating clinical and basic evidence. This review focuses on the current knowledge of the applications and mechanisms of letrozole in female infertility, and raises various questions on how it could be used more effectively.
Letrozole, an aromatase inhibitor that blocks estrogen synthesis by inhibiting the final step of the estrogen biosynthetic pathway, has been used in the applications of a wide range of infertility settings. It has been more than 20 years since the initial clinical trial of letrozole for ovulation induction. In light of the accumulating clinical and basic evidence, the efficacy and safety of letrozole have been identified. This mini review focuses on our current knowledge of the applications and mechanisms of letrozole for female infertility and various questions are put forward about how letrozole could be more effectively used.
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