Journal
FRONTIERS IN GENETICS
Volume 12, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fgene.2021.682904
Keywords
long non-coding RNA; kidney disease; renal fibrosis; fibrosis; diabetic nephropathy
Categories
Funding
- National Natural Science Foundation of China [81770693]
- Natural Science Foundation of Hunan province [2020JJ4870]
Ask authors/readers for more resources
Renal fibrosis is a pathological process in chronic kidney disease that leads to renal failure, involving complex molecular mechanisms. Long non-coding RNAs have been implicated in the development and progression of renal fibrosis, offering potential diagnostic, prognostic, and therapeutic applications in RF-associated diseases and CKD transition. Future research directions focus on the role of lncRNAs in RF development and treatment.
Renal fibrosis (RF) is a pathological process that culminates in terminal renal failure in chronic kidney disease (CKD). Fibrosis contributes to progressive and irreversible decline in renal function. However, the molecular mechanisms involved in RF are complex and remain poorly understood. Long non-coding RNAs (lncRNAs) are a major type of non-coding RNAs, which significantly affect various disease processes, cellular homeostasis, and development through multiple mechanisms. Recent investigations have implicated aberrantly expressed lncRNA in RF development and progression, suggesting that lncRNAs play a crucial role in determining the clinical manifestation of RF. In this review, we comprehensively evaluated the recently published articles on lncRNAs in RF, discussed the potential application of lncRNAs as diagnostic and/or prognostic biomarkers, proposed therapeutic targets for treating RF-associated diseases and subsequent CKD transition, and highlight future research directions in the context of the role of lncRNAs in the development and treatment of RF.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available