Journal
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY
Volume 8, Issue 7, Pages 1508-1514Publisher
WILEY
DOI: 10.1002/acn3.51386
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Funding
- Department of Anesthesia, Critical Care & Pain Medicine, Massachusetts General Hospital
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Schwannomas can cause severe pain, and the upregulation of FGF7 in painful tumors may be associated with the development of pain. Behavioral support was found in a xenograft human NF2-schwannoma model, where over-expression of FGF7 induced pain behavior in nude mice.
Schwannomas are benign neoplasms that can cause gain- and loss-of-function neurological phenotypes, including severe, intractable pain. To investigate the molecular mechanisms underlying schwannoma-associated pain we compared the RNA sequencing profile of painful and non-painful schwannomas from NF2 patients. Distinct segregation of painful and non-painful tumors by gene expression patterns was observed. Differential expression analysis showed the upregulation of fibroblast growth factor 7 (FGF7) in painful schwannomas. Behavioral support for this finding was observed using a xenograft human NF2-schwannoma model in nude mice. In this model, over-expression of FGF7 in intra-sciatically implanted NF2 tumor cells generated pain behavior compared with controls.
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