Journal
MATERIALS & DESIGN
Volume 205, Issue -, Pages -Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.matdes.2021.109717
Keywords
Pelvic organ prolapse; Nylon; Collagen; LBL-structured mats; Biocompatibility
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Funding
- National Natural Science Foundation of China [51873157]
- Hubei Provincial Key Research and Development Project [2020BAA029]
- Natural Science Foundation for Distinguished Young Scholars of Hubei Province of China [2020CFA105]
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The development of a novel, biocompatible mesh for the treatment of pelvic organ prolapse using chitosan and collagen coating on nanofiber mats has shown promising results in facilitating cell growth and demonstrating excellent antibacterial activity. Through systematic chemical characterization and cell biology experiments, the modified mesh has shown significant changes in composition and structure, indicating its potential as implant material for pelvic organ prolapse patients.
Developing novel, lightweight and biocompatible mesh for pelvic organ prolapse, a gynecological disease, has attracted the global interest of biomedical researchers. In our study, polycaprolactone and nylon 6 mats with excellent mechanical properties were fabricated via co-electrospinning. Positively charged chitosan with antimicrobial properties and negatively charged collagen with good biocompatibility were then assembled on the nanofiber mats via layer by layer (LBL) technology. SEM and mechanical property tests showed that LBL deposition increased the nanofibers' diameter and elastic modulus. To evaluate the successful deposition process, the zeta potential, The Fourier-transform infrared, X-ray diffraction, and Xray photoelectron spectroscopy analyses were conducted to systematically study the mats' chemical characterization. The results indicated that the mats' composition and structure significantly changed after LBL modification. Cell biology experiments demonstrated that the LBL-structured mats can facilitate cell growth, proliferation, and adhesion. Antibacterial tests confirmed their excellent antibacterial activity. Chitosan/Collagen-coated Polycaprolactone/Nylon 6 mats demonstrate considerable potential as implant materials for pelvic reestablishment in pelvic organ prolapse patients. (c) 2021 The Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
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