Journal
ACS CENTRAL SCIENCE
Volume 7, Issue 9, Pages 1454-1462Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acscentsci.1c00594
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Funding
- NIH [GM62160, GM125271, 1721852308]
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The complexity and irreproducibility of glycosylation reactions hinder the progress of glycosciences. Applying the steady-state hypothesis to transient oxocarbenium ion-counterion pair intermediates reveals the significance of factors like concentration, temperature in glycosylation stereoselectivity. Guidelines have been proposed for the practice of O-glycosylation reactions, allowing for the establishment of more reproducible and practical protocols.
The complexity and irreproducibility of glycosylation reactions retard progress the glycosciencs. Application of the steady-state hypothesis to transient oxocarbenium ion-counterion pair intermediates reveals the importance of concentration, temperature, and other factors in glycosylation stereoselectivity. Guidelines are then adduced for the practice of O-glycosylation reactions on the oasis of which more reproducible, practical protocols can be established.
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