Journal
BRITISH JOURNAL OF HAEMATOLOGY
Volume 169, Issue 6, Pages 843-850Publisher
WILEY-BLACKWELL
DOI: 10.1111/bjh.13382
Keywords
multiple myeloma; extraosseous plasmacytoma; extramedullary disease; bortezomib; lenalidomide
Categories
Funding
- National Institutes of Health [R01 CA127435, R01 CA179483]
- Shawna Ashlee Corman Investigatorship in Multiple Myeloma Research
- de Gunzburg Myeloma Research Fund
- Cobb Family Myeloma Research Fund
- Chambers Family Advanced Myeloma Research Fund
- Leukemia and Lymphoma Society
- Multiple Myeloma Research Foundation
- RJ Corman Multiple Myeloma Research Fund
Ask authors/readers for more resources
Proteasome inhibitors (PI) and immunomodulatory agents (IMIDs) have improved the overall survival (OS) of patients with multiple myeloma (MM), but concerns have been raised about increased incidence of extramedullary disease (EMD) after the combined use of PIs and IMIDs for upfront therapy. We evaluated whether the addition of lenalidomide to bortezomib-based front-line regimens precipitated earlier development of EMD. We reviewed the charts of 117 MM patients (median follow-up from diagnosis 61years; range 01-102years) enrolled in eight clinical trials of first-line treatment with bortezomib-based regimens, with or without lenalidomide. We assessed development of EMD as extraosseous (distant from bone) or osseous (originating from bone) plasmacytomas. The primary endpoint was time from diagnosis until development of EMD, based on imaging, biopsy and/or physical examination. Any form of EMD at progression was observed in 40 (342%) patients, including 21 (18%) osseous, 8 (7%) extraosseous and 11 (9%) both osseous and extraosseous. Median OS was 09years (range 01-48years) after extraosseous EMD development. Sensitivity analyses with follow-up times truncated at 5years detected no statistically significant difference in rates of any EMD form between the two groups (P>02 for each comparison). Therefore, we observed no evidence that bortezomib-lenalidomide-based front-line therapy precipitates earlier EMD.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available