Peroxiredoxins wear many hats: Factors that fashion their peroxide sensing personalities

Peroxiredoxins (Prdxs) sense and assess peroxide levels, and signal through protein interactions. Understanding the role of the multiple structural and post-translational modification (PTM) layers that tunes the peroxiredoxin specificities is still a challenge. In this review, we give a tabulated overview on what is known about human and bacterial peroxiredoxins with a focus on structure, PTMs, and protein-protein interactions. Armed with numerous cellular and atomic level experimental techniques, we look at the future and ask ourselves what is still needed to give us a clearer view on the cellular operating power of Prdxs in both stress and non-stress conditions.

Automated summary

This review provides a tabulated overview of human and bacterial peroxiredoxins, focusing on structure, post-translational modifications, and protein-protein interactions. The study aims to understand the cellular operating power of Prdxs in both stress and non-stress conditions, utilizing various experimental techniques at cellular and atomic levels. Future research is needed to gain a clearer view on the specificities and functions of peroxiredoxins in different cellular contexts.