4.3 Review

Fluorescence Guided Surgery

Journal

Publisher

IOP Publishing Ltd
DOI: 10.1088/2050-6120/ac1dbb

Keywords

fluorescence guided surgery; intraoperative surgery; fluorescence imaging; SPAD arrays; fluorescence probes; fluorescence lifetime; FLIM

Funding

  1. EPSRC
  2. MRC Centre for Doctoral Training in Optical Medical Imaging (OPTIMA)
  3. HORIBA Jobin Yvon IBH Ltd
  4. EPSRC QuantIC Quantum Technology Hub

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Fluorescence guided surgery, with its advantages such as higher contrast, sensitivity, and ease of operation, is gaining more interest. Despite some developments, there are still limitations that need to be overcome.
Fluorescence guided surgery (FGS) is an imaging technique that allows the surgeon to visualise different structures and types of tissue during a surgical procedure that may not be as visible under white light conditions. Due to the many potential advantages of fluorescence guided surgery compared to more traditional clinical imaging techniques such as its higher contrast and sensitivity, less subjective use, and ease of instrument operation, the research interest in fluorescence guided surgery continues to grow over various key aspects such as fluorescent probe development and surgical system development as well as its potential clinical applications. This review looks to summarise some of the emerging opportunities and developments that have already been made in fluorescence guided surgery in recent years while highlighting its advantages as well as limitations that need to be overcome in order to utilise the full potential of fluorescence within the surgical environment.

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