Journal
MATERIALS RESEARCH EXPRESS
Volume 8, Issue 7, Pages -Publisher
IOP Publishing Ltd
DOI: 10.1088/2053-1591/ac0fad
Keywords
CeO2-NPs; spinal cord injury; green synthesis; pediatric leukemia
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The study introduces a biocompatible cerium oxide nanoparticles synthesized through a biosynthetic approach, showing regenerative and neuroprotective effects on adult rat spinal cord neurons and indicating potential applications in spinal cord injury treatment. Additionally, CeO2-NPs demonstrate high cytotoxicity against pediatric leukemia cells, suggesting therapeutic potential for future treatment. The research also emphasizes the potential of CeO2-NPs for spinal cord injury treatment through nano-based therapy.
Injury prognosis, and treatment are one of the major objectives of nursing care during the treatment of spinal cord injury (SCI). Here, we developed a novel, biocompatible Cerium oxide nanoparticles (CeO2-NPs) through biosynthetic approach that can be used for the treatment of spinal cord injury in nursing care. CeO2-NPs were green fabricated utilizing leaf extract of Azadirachta indica. The fabricated nanoparticles still maintained the cubic-structure that was revealed by the x-ray diffraction (X-RD) analysis. Transmission electron microscopy (TEM) images displayed the sphere shape of nanoparticles having 15 nm particle size. The stretching bands of Ce-O bond were noticed at 457 cm(-1) and 451 cm(-1) from the Raman and Fourier-transform Infrared (FT-IR) spectra, correspondingly. On the other side, biological investigations demonstrated that the single dose application of CeO2-NPs at nanomolar concentration is regenerative, bio-compatible and offers a considerable neuro-protective effect on the neurons in spinal-cord of an adult rat. Neuronal function retention is showed in electro-physiological (electrography) recordings and plausibility of its uses in preventing ischemic-insult is revealed from the assay of oxidative injury. This work explored the possibility of usage of prepared CeO2-NPs for SCI treatment. Furthermore, examination of green fabricated CeO2-NPs on paediatric leukaemia (CCRF-SB) cells were found to potentiate cytotoxicity indicating their therapeutic potential for future treatment of paediatric cancer. On the other hand, the current study also highlights the potential effect of CeO2-NPs on treatment of SCI through nano-based therapy.
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