Journal
JOURNAL OF PAIN RESEARCH
Volume 14, Issue -, Pages 2767-2776Publisher
DOVE MEDICAL PRESS LTD
DOI: 10.2147/JPR.S323372
Keywords
neural dosing; pharmacology; neuromodulation; spinal cord stimulation; electrical dosing
Categories
Funding
- Abbott
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Spinal cord stimulation has experienced significant growth in the past 50 years, but optimization of electrical dosing remains a challenge. Current research findings can offer insight for developing more rational approaches in the future.
Spinal cord stimulation has seen unprecedented growth in new technology in the 50 years since the first subdural implant. As we continue to grow our understanding of spinal cord stimulation and relevant mechanisms of action, novel questions arise as to electrical dosing optimization. Programming adjustment - dose titration - is often a process of trial and error that can be time-consuming and frustrating for both patient and clinician. In this report, we review the current preclinical and clinical knowledge base in order to provide insights that may be helpful in developing more rational approaches to spinal cord stimulation dosing. We also provide key conclusions that may help in directing future research into electrical dosing, given the advent of newer waveforms outside traditional programming parameters.
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