COVID-19 vaccines and decreased transmission of SARS-CoV-2

Letter Medicine, General & Internal

COVID-19 pandemic: vaccine and new monoclonal antibodies, point of view

Antonio Vitiello et al.

IRISH JOURNAL OF MEDICAL SCIENCE (2022)

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Letter Medicine, General & Internal

Remdesivir and COVID-19

Francesco Ferrara et al.

IRISH JOURNAL OF MEDICAL SCIENCE (2021)

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Review Pharmacology & Pharmacy

Drugs acting on the renin-angiotensin system and SARS-CoV-2

Antonio Vitiello et al.

Summary: This article discusses the potential of therapeutic agents acting on the renin-angiotensin system (RAS) to modulate the concentration of ACE-2 and combat SARS-CoV-2 infection. It also highlights the possible negative effects of the ACE/Ang-II/AT-1r axis and the potential beneficial role of the ACE-2/Ang 1-7/MasR axis in ARDS caused by SARS-CoV-2, suggesting the possibility of targeting various RAS components with drug treatments to improve clinical outcomes.

DRUG DISCOVERY TODAY (2021)

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Review Immunology

Pharmacological approach for the reduction of inflammatory and prothrombotic hyperactive state in COVID-19 positive patients by acting on complement cascade

A. Vitiello et al.

Summary: This passage discusses the novel coronavirus SARS-CoV-2 and the ongoing global pandemic COVID-19, highlighting the importance of understanding the immunological and inflammatory processes of the infection. It also emphasizes the significance of pharmacological approaches to regulating the uncontrolled inflammatory/immunologic response in severe cases of COVID-19 infection.

HUMAN IMMUNOLOGY (2021)

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Letter Medicine, General & Internal

Remdesivir versus ritonavir/lopinavir in COVID-19 patients

Antonio Vitiello et al.

IRISH JOURNAL OF MEDICAL SCIENCE (2021)

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Letter Medicine, General & Internal

Remdesivir and COVID-19 infection, therapeutic benefits or unnecessary risks?

Antonio Vitiello et al.

IRISH JOURNAL OF MEDICAL SCIENCE (2021)

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Editorial Material Medicine, General & Internal

Oxford-AstraZeneca COVID-19 vaccine efficacy

Maria Deloria Knoll et al.

LANCET (2021)

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Article Medicine, General & Internal

Safety and efficacy of the ChAdOx1 nCoV-19 vaccine (AZD1222) against SARS-CoV-2: an interim analysis of four randomised controlled trials in Brazil, South Africa, and the UK

Merryn Voysey et al.

Summary: The ChAdOx1 nCoV-19 vaccine has been shown to have an acceptable safety profile and effectiveness against symptomatic COVID-19, with higher efficacy observed in the group that received a low dose followed by a standard dose.

LANCET (2021)

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Review Biochemistry & Molecular Biology

COVID-19: A Global Challenge with Old History, Epidemiology and Progress So Far

Mujeeb Khan et al.

Summary: The article summarizes the three deadly pandemics associated with novel coronaviruses that humans have witnessed in the twenty-first century: SARS, MERS, and COVID-19. Specifically, it describes the epidemiological characteristics of COVID-19, such as transmission, death rate, and discusses various treatment strategies and different approaches to vaccine development.

MOLECULES (2021)

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Article Pharmacology & Pharmacy

Efficacy of synthetic glucocorticoids in COVID-19 endothelites

Francesco Ferrara et al.

Summary: The global pandemic caused by the new coronavirus SARS-CoV-2 (COVID-19) has led to severe respiratory and multi-organ complications. While vaccines have been authorized, ongoing randomized trials aim to find effective and safe treatments. Among these, glucocorticoids, particularly dexamethasone, show beneficial effects in severe COVID-19 cases.

NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY (2021)

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Article Medicine, General & Internal

Interim Results of a Phase 1-2a Trial of Ad26.COV2.S Covid-19 Vaccine

J. Sadoff et al.

Summary: The study conducted a multicenter, placebo-controlled, phase 1-2a trial, with participants randomly assigned to receive the Ad26.COV2.S vaccine. The results showed that the safety and immunogenicity profiles of the vaccine support further development.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

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Review Cardiac & Cardiovascular Systems

Colchicine and SARS-CoV-2: Management of the hyperinflammatory state

Antonio Vitiello et al.

Summary: The global COVID-19 pandemic is ongoing with the licensing of the first Sars-CoV-2 vaccine by the EMA in December 2020. Studies suggest that colchicine, an anti-inflammatory therapy, may be effective at modulating and controlling the inflammatory state associated with severe COVID-19 complications. It is important to conduct well-organized clinical studies to further explore the potential of colchicine in treating and preventing cytokine storms in patients with SARS-CoV-2 infection.

RESPIRATORY MEDICINE (2021)

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Article Cardiac & Cardiovascular Systems

Scientific Hypothesis for Treatment of COVID-19′s Lung Lesions by Adjusting ACE/ACE2 Imbalance

F. Ferrara et al.

Summary: The global COVID-19 pandemic, caused by the new Coronavirus SARS-CoV-2, has led to millions of deaths worldwide. The ACE-2 protein plays a crucial role in the infection process, making it a potential target for pharmacological intervention in treating COVID-19. Understanding the interactions between RAS, ACE-2, and ACE/ACE2 balance could provide valuable insights for developing effective treatments for the virus.

CARDIOVASCULAR TOXICOLOGY (2021)

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Article Biochemistry & Molecular Biology

Initial report of decreased SARS-CoV-2 viral load after inoculation with the BNT162b2 vaccine

Matan Levine-Tiefenbrun et al.

Summary: COVID-19 vaccines not only provide protection to individual vaccinees, but may also reduce viral load in breakthrough infections, potentially leading to lower infectiousness and further suppressing virus spread.

NATURE MEDICINE (2021)

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Article Medicine, General & Internal