Journal
INFLAMMOPHARMACOLOGY
Volume 29, Issue 5, Pages 1379-1387Publisher
SPRINGER BASEL AG
DOI: 10.1007/s10787-021-00865-0
Keywords
Colchicine; Non-ST-elevated myocardial infarction; hs-CRP; Inflammation
Categories
Funding
- Mashhad University of Medical Sciences [970561]
Ask authors/readers for more resources
This study aimed to evaluate the effects of colchicine on hs-CRP levels in NSTEMI patients. The results showed that colchicine significantly reduced hs-CRP levels in NSTEMI patients, with a stronger effect compared to placebo. However, neither colchicine nor placebo treatment could achieve hs-CRP levels lower than 2 mg/L.
Myocardial infarction without ST-segment elevation (NSTEMI) is considered an inflammatory disorder associated with a high mortality rate worldwide. High-sensitivity C-reactive protein (hs-CRP) is an important inflammatory marker for NSTEMI and related to cardiovascular events. Colchicine, as a potent anti-inflammatory drug, is frequently prescribed for the treatment of gout and pericarditis. The present study aimed to evaluate the effects of colchicine, as an anti-inflammatory drug, on hs-CRP levels in NSTEMI patients. We performed a randomised, double-blind, placebo-controlled trial involving 150 NSTEMI patients referred to Imam Reza and Ghaem Hospitals affiliated to Mashhad University of Medical Sciences. The patients were randomised to receive colchicine or placebo along with optimal medications for 30 days. The hs-CRP was measured at the admission and end of the study. Our results revealed that, in both colchicine and placebo groups, hs-CRP levels were significantly mitigated in NSTEMI patients compared to baseline (P < 0.001). However, the decreasing properties of colchicine on hs-CRP levels were remarkably stronger than placebo following the 30 days of treatment (P < 0.001). Nevertheless, neither colchicine nor placebo treatment could achieve hs-CRP levels lower than 2 mg/L. There were no significant differences between the effects of colchicine on the hs-CRP decrease in diabetic and non-diabetic, male and female, and normal and preserved LVEF NSTEMI patients. It can be concluded that colchicine may prevent the disease progression and succedent cardiovascular events in NSTEMI patients by attenuating the inflammation.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available