CAR-T Cell Therapy: Mechanism, Management, and Mitigation of Inflammatory Toxicities

Engineered T cell therapies such as chimeric antigen receptor (CAR) expressing T cells (CAR-T cells) have great potential to treat many human diseases; however, inflammatory toxicities associated with these therapies present safety risks and can greatly limit its widespread use. This article briefly reviews our current understanding of mechanisms for inflammatory toxicities during CAR T-cell therapy, current strategies for management and mitigation of these risks and highlights key areas of knowledge gap for future research.

Automated summary

Engineered T cell therapies like CAR-T cells have potential to treat diseases, but inflammatory toxicities pose safety risks. Research is ongoing to understand mechanisms and strategies for managing these toxicities, with key knowledge gaps for future exploration.