Journal
FRONTIERS IN IMMUNOLOGY
Volume 12, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2021.653208
Keywords
tryptophan; kynurenine; indole; microbiome & dysbiosis; mucosal immmunity; aryl hydrocarbon receptor; serotonin
Categories
Funding
- National Institute of Diabetes and Digestive and Kidney Diseases of the National Institutes of Health [R01DK09945]
- National Institute of General Medical Sciences of the National Institutes of Health [U54GM115371]
- United States Department of Agriculture National Institute of Food and Agriculture Hatch Project [1015883]
- Cole-Tierney Award (MSU)
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Tryptophan is an essential amino acid involved in the synthesis of neurotransmitters and signaling molecules, regulating various physiological effects through the metabolism and production by both host cells and microbiome.
Tryptophan (Trp) is an essential amino acid primarily derived from the diet for use by the host for protein synthesis. The intestinal tract is lined with cells, both host and microbial, that uptake and metabolize Trp to also generate important signaling molecules. Serotonin (5-HT), kynurenine and its downstream metabolites, and to a lesser extent other neurotransmitters are generated by the host to signal onto host receptors and elicit physiological effects. 5-HT production by neurons in the CNS regulates sleep, mood, and appetite; 5-HT production in the intestinal tract by enterochromaffin cells regulates gastric motility and inflammation in the periphery. Kynurenine can signal onto the aryl hydrocarbon receptor (AHR) to elicit pleiotropic responses from several cell types including epithelial and immune cells, or can be further metabolized into bioactive molecules to influence neurodegenerative disease. There is a remarkable amount of cross-talk with the microbiome with regard to tryptophan metabolites as well. The gut microbiome can regulate the production of host tryptophan metabolites and can use dietary or recycled trp to generate bioactive metabolites themselves. Trp derivatives like indole are able to signal onto xenobiotic receptors, including AHR, to elicit tolerogenic effects. Here, we review studies that demonstrate that tryptophan represents a key intra-kingdom signaling molecule.
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