Journal
FRONTIERS IN IMMUNOLOGY
Volume 12, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2021.681810
Keywords
inflammation; single nucleotide polymorphisms; lipopolysaccharide-binding protein; infections; inflammatory diseases; metabolic disorders; cancers
Categories
Funding
- National Science Foundation of China [81971875]
- University Natural Science Foundation of Anhui Province [KJ2019A0220]
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Inflammation, driven by the immune response, is a key factor in various diseases. Genetic variations in pivotal immune response genes, particularly SNPs, may affect disease predisposition and clinical outcomes. The LBP gene, which plays a crucial role in inflammation, may be impacted by SNPs and influence infections, inflammatory diseases, metabolic disorders, and cancers.
Inflammation, which is induced by the immune response, is recognized as the driving factor in many diseases, including infections and inflammatory diseases, metabolic disorders and cancers. Genetic variations in pivotal genes associated with the immune response, particularly single nucleotide polymorphisms (SNPs), may account for predisposition and clinical outcome of diseases. Lipopolysaccharide (LPS)-binding protein (LBP) functions as an enhancer of the host response to LPS, the main component of the outer membrane of gram-native bacteria. Given the crucial role of LBP in inflammation, we will review the impact of SNPs in the LBP gene on infections and inflammatory diseases, metabolic disorders and cancers.
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