4.8 Review

Leveraging NKG2D Ligands in Immuno-Oncology

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Caspase-dependent immunogenicity of doxorubicin-induced tumor cell death

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NKG2D function protects the host from tumor initiation

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Systemic NKG2D down-regulation impairs NK and CD8 T cell responses in vivo

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CpG and double-stranded RNA trigger human NK cells by Toll-like receptors: Induction of cytokine release and cytotoxicity against tumors and dendritic cells

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ULBP4 is a novel ligand for human NKG2D

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Transforming growth factor β1 inhibits expression of NKp30 and NKG2D receptors:: Consequences for the NK-mediated killing of dendritic cells

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Cutting edge: Down-regulation of MICA on human tumors by proteolytic shedding

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Codominant expression of the polymorphic MICA alloantigens encoded by genes in the HLA region

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Ectopic expression of retinoic acid early inducible-1 gene (RAE-1) permits natural killer cell-mediated rejection of a MHC class I-bearing tumor in vivo

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Rae1 and H60 ligands of the NKG2D receptor stimulate tumour immunity

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