4.8 Review

Metabolic Reprogramming of Immune Cells at the Maternal-Fetal Interface and the Development of Techniques for Immunometabolism

Related references

Note: Only part of the references are listed.
Editorial Material Oncology

Whole-genome sequencing of East Asian lung cancers reveals new germline pathogenic variants

Semanti Mukherjee et al.

Summary: In this study, Wang et al. used whole-genome sequencing to comprehensively analyze common and rare variants associated with lung cancer risk in individuals with East Asian ancestry. Their findings suggest that rare promoter variants in the BRCA2 gene are associated with an increased risk of lung cancer.

CANCER CELL (2022)

Review Biochemical Research Methods

CE-MS for metabolomics: Developments and applications in the period 2018-2020

Wei Zhang et al.

Summary: Capillary electrophoresis-mass spectrometry (CE-MS) has become a mature analytical technique in metabolomics, particularly for analyzing polar and charged metabolites efficiently. In recent years, there have been advancements in CE-MS methods and strategies for metabolomics, including improved interfacing techniques for coupling CE to MS, profiling metabolites in volume-restricted samples, and enhancing metabolic coverage.

ELECTROPHORESIS (2021)

Article Biotechnology & Applied Microbiology

Single-cell metabolic profiling of human cytotoxic T cells

Felix J. Hartmann et al.

Summary: This antibody-based method allows profiling of metabolic protein expression and regulation in single cells using mass spectrometry while characterizing cellular phenotype. The approach was validated using mass cytometry and applied to clinical samples, revealing tissue-restricted, metabolically repressed immune cells in human colorectal carcinoma. The combination with multiplexed ion beam imaging unveiled the spatial organization of metabolic programs in human tissues.

NATURE BIOTECHNOLOGY (2021)

Review Medicine, Research & Experimental

Dendritic cells in pregnancy and pregnancy-associated diseases

Ran Wei et al.

Summary: Dendritic cells play a critical immuno-modulating role in pregnancy, interacting closely with other immune components and the endocrine system. Aberrant DC activities have been linked to various pregnancy-associated diseases.

BIOMEDICINE & PHARMACOTHERAPY (2021)

Article Oncology

TGFβ drives NK cell metabolic dysfunction in human metastatic breast cancer

Karen Slattery et al.

Summary: Patients with metastatic breast cancer exhibit metabolic deficits in circulating NK cells, including reduced glycolysis and oxidative phosphorylation, as well as morphological alterations in mitochondria. Transforming growth factor-beta (TGFβ) is identified as a key driver of this phenotype. Blocking TGFβ and/or GARP can restore NK cell metabolism and function, presenting a novel target for improving NK cell-based immunotherapies.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2021)

Review Immunology

Tissue Nutrient Environments and Their Effect on Regulatory T Cell Biology

Julianna Blagih et al.

Summary: Regulatory T cells play a crucial role in mitigating inflammation and their function is influenced by nutrients. Mitochondrial oxidative metabolism is essential for Treg differentiation and adaptability. Tregs demonstrate different adaptability in various tissue environments, such as their ability to survive in tumor tissues.

FRONTIERS IN IMMUNOLOGY (2021)

Review Immunology

A guide to interrogating immunometabolism

Kelsey Voss et al.

Summary: Immunologists are revisiting the importance of metabolic pathways and offering a framework to explore immunometabolism, highlighting the power of metabolism in immunology through different methodologies. They provide recommendations for developing and testing metabolic hypotheses, aiming to help researchers avoid common mistakes and understand the impact of metabolism on immunity.

NATURE REVIEWS IMMUNOLOGY (2021)

Article Medicine, Research & Experimental

Decidual CD8(+)T cells exhibit both residency and tolerance signatures modulated by decidual stromal cells

Lu Liu et al.

JOURNAL OF TRANSLATIONAL MEDICINE (2020)

Review Cell Biology

Immunometabolism in the Single-Cell Era

Maxim N. Artyomov et al.

CELL METABOLISM (2020)

Review Endocrinology & Metabolism

Shaping of Dendritic Cell Function by the Metabolic Micro-Environment

Eline Constance Brombacher et al.

FRONTIERS IN ENDOCRINOLOGY (2020)

Review Immunology

The role of immunity in the pathogenesis and development of pre-eclampsia

Hui-Qing Lu et al.

SCANDINAVIAN JOURNAL OF IMMUNOLOGY (2019)

Review Biochemistry & Molecular Biology

Role of the Monocyte-Macrophage System in Normal Pregnancy and Preeclampsia

Polina Vishnyakova et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

Article Chemistry, Analytical

Deciphering Metabolic Heterogeneity by Single-Cell Analysis

Tom M. J. Evers et al.

ANALYTICAL CHEMISTRY (2019)

Article Immunology

Mitochondrial fragmentation limits NK cell-based tumor immunosurveillance

Xiaohu Zheng et al.

NATURE IMMUNOLOGY (2019)

Review Immunology

Dendritic cell subsets in T cell programming: location dictates function

S. C. Eisenbarth

NATURE REVIEWS IMMUNOLOGY (2019)

Editorial Material Cell Biology

Intricacies in the cross talk between metabolic enzymes, RNA, and protein translation

Yuan Lv et al.

JOURNAL OF MOLECULAR CELL BIOLOGY (2019)

Review Immunology

New Paradigm in the Role of Regulatory T Cells During Pregnancy

Sayaka Tsuda et al.

FRONTIERS IN IMMUNOLOGY (2019)

Article Multidisciplinary Sciences

Mixed signature of activation and dysfunction allows human decidual CD8(+) T cells to provide both tolerance and immunity

Anita van der Zwan et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)

Review Immunology

Immunometabolism, pregnancy, and nutrition

Kristin Thiele et al.

SEMINARS IN IMMUNOPATHOLOGY (2018)

Article Immunology

Downregulation of ILT4+ dendritic cells in recurrent miscarriage and recurrent implantation failure

Su Liu et al.

AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY (2018)

Article Multidisciplinary Sciences

Amino acid-dependent cMyc expression is essential for NK cell metabolic and functional responses in mice

Roisin M. Loftus et al.

NATURE COMMUNICATIONS (2018)

Review Biochemistry & Molecular Biology

Krebs Cycle Reimagined: The Emerging Roles of Succinate and Itaconate as Signal Transducers

Michael P. Murphy et al.

Article Biochemical Research Methods

Metal-isotope-tagged monoclonal antibodies for high-dimensional mass cytometry

Guojun Han et al.

NATURE PROTOCOLS (2018)

Article Agriculture, Dairy & Animal Science

Tim-3 and PD-1 regulate CD8+ T cell function to maintain early pregnancy in mice

Yuan-Yuan Xu et al.

JOURNAL OF REPRODUCTION AND DEVELOPMENT (2017)

Article Immunology

The role of decidual NK cells in pregnancies with impaired vascular remodelling

Judith E. Cartwright et al.

JOURNAL OF REPRODUCTIVE IMMUNOLOGY (2017)

Article Multidisciplinary Sciences

Anti-inflammatory effect of IL-10 mediated by metabolic reprogramming of macrophages

W. K. Eddie Ip et al.

SCIENCE (2017)

Editorial Material Multidisciplinary Sciences

Inflammation by way of macrophage metabolism

Agnieszka M. Kabat et al.

SCIENCE (2017)

Review Biochemical Research Methods

Direct infusion mass spectrometry for metabolomic phenotyping of diseases

Raul Gonzalez-Dominguez et al.

BIOANALYSIS (2017)

Article Multidisciplinary Sciences

BCAT1 controls metabolic reprogramming in activated human macrophages and is associated with inflammatory diseases

Adonia E. Papathanassiu et al.

NATURE COMMUNICATIONS (2017)

Article Multidisciplinary Sciences

Glucose represses dendritic cell-induced T cell responses

Simon J. Lawless et al.

NATURE COMMUNICATIONS (2017)

Review Immunology

Modulators of the Balance between M1 and M2 Macrophages during Pregnancy

Yong-Hong Zhang et al.

FRONTIERS IN IMMUNOLOGY (2017)

Article Immunology

Srebp-controlled glucose metabolism is essential for NK cell functional responses

Nadine Assmann et al.

NATURE IMMUNOLOGY (2017)

Article Obstetrics & Gynecology

Adaptation of Maternal-Fetal Physiology to Exercise in Pregnancy: The Basis of Guidelines for Physical Activity in Pregnancy

Edward R. Newton et al.

CLINICAL MEDICINE INSIGHTS-WOMENS HEALTH (2017)

Article Chemistry, Analytical

Single-Cell Mass Spectrometry of Metabolites Extracted from Live Cells by Fluidic Force Microscopy

Orane Guillaume-Gentil et al.

ANALYTICAL CHEMISTRY (2017)

Review Medicine, Research & Experimental

Immune regulatory network in successful pregnancy and reproductive failures

Mahnaz Ghaebi et al.

BIOMEDICINE & PHARMACOTHERAPY (2017)

Review Immunology

Immunometabolism governs dendritic cell and macrophage function

Luke A. J. O'Neill et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2016)

Article Immunology

Association of peripheral blood dendritic cells with recurrent pregnancy loss: a case-controlled study

Chunyu Huang et al.

AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY (2016)

Article Chemistry, Analytical

A New Method and Mass Spectrometer Design for TOF-SIMS Parallel Imaging MS/MS

Gregory L. Fisher et al.

ANALYTICAL CHEMISTRY (2016)

Article Cell Biology

Macrophage Metabolism Controls Tumor Blood Vessel Morphogenesis and Metastasis

Mathias Wenes et al.

CELL METABOLISM (2016)

Article Immunology

Metabolic Reprogramming Supports IFN-γ Production by CD56bright NK Cells

Sinead E. Keating et al.

JOURNAL OF IMMUNOLOGY (2016)

Article Chemistry, Multidisciplinary

Supramolecular Probes for Assessing Glutamine Uptake Enable Semi-Quantitative Metabolic Models in Single Cells

Min Xue et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2016)

Article Multidisciplinary Sciences

Metabolic maintenance of cell asymmetry following division in activated T lymphocytes

Katherine C. Verbist et al.

NATURE (2016)

Article Biochemistry & Molecular Biology

Lipid profiling of polarized human monocyte-derived macrophages

J. Rafael Montenegro-Burke et al.

PROSTAGLANDINS & OTHER LIPID MEDIATORS (2016)

Article Multidisciplinary Sciences

Interferon Regulatory Factor 4 controls TH1 cell effector function and metabolism

Justus Mahnke et al.

SCIENTIFIC REPORTS (2016)

Article Cell Biology

Mitochondrial Dysfunction Prevents Repolarization of Inflammatory Macrophages

Jan Van den Bossche et al.

CELL REPORTS (2016)

Review Biochemistry & Molecular Biology

Metabolic Regulation of Histone Post-Translational Modifications

Jing Fan et al.

ACS CHEMICAL BIOLOGY (2015)

Article Nutrition & Dietetics

Dietary Glutamine Supplementation Partly Reverses Impaired Macrophage Function Resulting From Overload Training in Rats

Weihua Xiao et al.

INTERNATIONAL JOURNAL OF SPORT NUTRITION AND EXERCISE METABOLISM (2015)

Article Medicine, Research & Experimental

mTORC1 and mTORC2 selectively regulate CD8+ T cell differentiation

Kristen N. Pollizzi et al.

JOURNAL OF CLINICAL INVESTIGATION (2015)

Article Immunology

Increased circulating interleukin-17 levels in preeclampsia

Attila Molvarec et al.

JOURNAL OF REPRODUCTIVE IMMUNOLOGY (2015)

Article Immunology

Immune mechanisms at the maternal-fetal interface: perspectives and challenges

Mercy PrabhuDas et al.

NATURE IMMUNOLOGY (2015)

Review Endocrinology & Metabolism

Metabolic Enzymes Enjoying New Partnerships as RNA-Binding Proteins

Alfredo Castello et al.

TRENDS IN ENDOCRINOLOGY AND METABOLISM (2015)

Article Multidisciplinary Sciences

PD-1 alters T-cell metabolic reprogramming by inhibiting glycolysis and promoting lipolysis and fatty acid oxidation

Nikolaos Patsoukis et al.

NATURE COMMUNICATIONS (2015)

Article Multidisciplinary Sciences

Metabolic Characterization of Polarized M1 and M2 Bone Marrow-derived Macrophages Using Real-time Extracellular Flux Analysis

Jan Van den Bossche et al.

JOVE-JOURNAL OF VISUALIZED EXPERIMENTS (2015)

Review Endocrinology & Metabolism

Cyclic Decidualization of the Human Endometrium in Reproductive Health and Failure

Birgit Gellersen et al.

ENDOCRINE REVIEWS (2014)

Article Developmental Biology

T cell behavior at the maternal-fetal interface

Patrice Nancy et al.

INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY (2014)

Article Immunology

mTORC1-Dependent Metabolic Reprogramming Is a Prerequisite for NK Cell Effector Function

Raymond P. Donnelly et al.

JOURNAL OF IMMUNOLOGY (2014)

Review Immunology

M1/M2 macrophage polarity in normal and complicated pregnancy

Mary B. Brown et al.

FRONTIERS IN IMMUNOLOGY (2014)

Article Immunology

Dendritic cells, monocytes and macrophages: a unified nomenclature based on ontogeny

Martin Guilliams et al.

NATURE REVIEWS IMMUNOLOGY (2014)

Review Immunology

Metabolic Regulation of T Lymphocytes

Nancie J. MacIver et al.

ANNUAL REVIEW OF IMMUNOLOGY, VOL 31 (2013)

Review Immunology

Interleukin-4-and Interleukin-13-Mediated Alternatively Activated Macrophages: Roles in Homeostasis and Disease

Steven J. Van Dyken et al.

ANNUAL REVIEW OF IMMUNOLOGY, VOL 31 (2013)

Article Multidisciplinary Sciences

Induction of pathogenic TH17 cells by inducible salt-sensing kinase SGK1

Chuan Wu et al.

NATURE (2013)

Article Multidisciplinary Sciences

Sodium chloride drives autoimmune disease by the induction of pathogenic TH17 cells

Markus Kleinewietfeld et al.

NATURE (2013)

Article Multidisciplinary Sciences

Succinate is an inflammatory signal that induces IL-1β through HIF-1α

G. M. Tannahill et al.

NATURE (2013)

Article Multidisciplinary Sciences

The Microbial Metabolites, Short-Chain Fatty Acids, Regulate Colonic Treg Cell Homeostasis

Patrick M. Smith et al.

SCIENCE (2013)

Article Multidisciplinary Sciences

Fueling Immunity: Insights into Metabolism and Lymphocyte Function

E. L. Pearce et al.

SCIENCE (2013)

Article Cell Biology

Genetic and Environmental Determinants of Human NK Cell Diversity Revealed by Mass Cytometry

Amir Horowitz et al.

SCIENCE TRANSLATIONAL MEDICINE (2013)

Article Cell Biology

Mast cells rescue implantation defects caused by c-kit deficiency

K. Woldacki et al.

CELL DEATH & DISEASE (2013)

Review Immunology

Mast cells as novel mediators of reproductive processes

Katja Woidacki et al.

FRONTIERS IN IMMUNOLOGY (2013)

Editorial Material Immunology

Metabolism and autophagy in the immune system: immunometabolism comes of age

Jeffrey C. Rathmell

IMMUNOLOGICAL REVIEWS (2012)

Review Biochemistry & Molecular Biology

Mechanisms of implantation: strategies for successful pregnancy

Jeeyeon Cha et al.

NATURE MEDICINE (2012)

Review Cell Biology

Metabolomics: the apogee of the omics trilogy

Gary J. Patti et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2012)

Article Biochemistry & Molecular Biology

Control of TH17/Treg Balance by Hypoxia-Inducible Factor 1

Eric V. Dang et al.

Article Immunology

Coordinate regulation of tissue macrophage and dendritic cell population dynamics by CSF-1

Elisa Tagliani et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2011)

Article Immunology

The Link between the PDL1 Costimulatory Pathway and Th17 in Fetomaternal Tolerance

Francesca D'Addio et al.

JOURNAL OF IMMUNOLOGY (2011)

Review Cell Biology

Maternal KIR and fetal HLA-C: a fine balance

Olympe Chazara et al.

JOURNAL OF LEUKOCYTE BIOLOGY (2011)

Article Immunology

The unique pathophysiology of early-onset severe preeclampsia: role of decidual T regulatory cells

Kristen H. Quinn et al.

JOURNAL OF REPRODUCTIVE IMMUNOLOGY (2011)

Article Developmental Biology

Immune cells in the placental bed

Judith N. Bulmer et al.

INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY (2010)

Article Immunology

Substrate Fate in Activated Macrophages: A Comparison between Innate, Classic, and Alternative Activation

Juan-Carlos Rodriguez-Prados et al.

JOURNAL OF IMMUNOLOGY (2010)

Article Immunology

DC within the pregnant mouse uterus influence growth and functional properties of uterine NK cells

Christian M. Karsten et al.

EUROPEAN JOURNAL OF IMMUNOLOGY (2009)

Article Immunology

Decidual leucocyte populations in early to late gestation normal human pregnancy

P. J. Williams et al.

JOURNAL OF REPRODUCTIVE IMMUNOLOGY (2009)

Article Multidisciplinary Sciences

Enhancing CD8 T-cell memory by modulating fatty acid metabolism

Erika L. Pearce et al.

NATURE (2009)

Article Multidisciplinary Sciences

mTOR regulates memory CD8 T-cell differentiation

Koichi Araki et al.

NATURE (2009)

Review Oncology

The LKB1-AMPK pathway: metabolism and growth control in tumour suppression

David B. Shackelford et al.

NATURE REVIEWS CANCER (2009)

Review Pharmacology & Pharmacy

Advances in measuring cellular bioenergetics using extracellular flux

David A. Ferrick et al.

DRUG DISCOVERY TODAY (2008)

Review Immunology

Orchestrating the orchestrators: chemokines in control of T cell traffic

Shannon K. Bromley et al.

NATURE IMMUNOLOGY (2008)

Review Immunology

The genetic and evolutionary balances in human NK cell receptor diversity

Peter Parham

SEMINARS IN IMMUNOLOGY (2008)

Article Multidisciplinary Sciences

Alloantigen-enhanced accumulation of CCR5+ 'effector' regulatory T cells in the gravid uterus

Marinos Kallikourdis et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)

Review Immunology

Immunology of placentation in eutherian mammals

Ashley Moffett et al.

NATURE REVIEWS IMMUNOLOGY (2006)

Article Immunology

Myeloid and lymphoid dendritic cells in normal pregnancy and pre-eclampsia

D Darmochwal-Kolarz et al.

CLINICAL AND EXPERIMENTAL IMMUNOLOGY (2003)

Review Immunology

Natural killer cells and pregnancy

A Moffett-King

NATURE REVIEWS IMMUNOLOGY (2002)