Metabolic Reprogramming of Immune Cells at the Maternal-Fetal Interface and the Development of Techniques for Immunometabolism

Immunity and metabolism are interdependent and coordinated, which are the core mechanisms for the body to maintain homeostasis. In tumor immunology research, immunometabolism has been a research hotspot and has achieved groundbreaking changes in recent years. However, in the field of maternal-fetal medicine, research on immunometabolism is still lagging. Reports directly investigating the roles of immunometabolism in the endometrial microenvironment and regulation of maternal-fetal immune tolerance are relatively few. This review highlights the leading techniques used to study immunometabolism and their development, the immune cells at the maternal-fetal interface and their metabolic features required for the implementation of their functions, explores the interaction between immunometabolism and pregnancy regulation based on little evidence and clues, and attempts to propose some new research directions and perspectives.

Automated summary

This review emphasizes the importance of immunometabolism in tumor immunology research and the groundbreaking changes it has achieved in recent years, while pointing out the lag in research on immunometabolism in the field of maternal-fetal medicine. It discusses the roles of immunometabolism in the endometrial microenvironment and its regulation of maternal-fetal immune tolerance, proposes some new research directions and perspectives.