4.8 Review

Immunogenic Cell Death-Based Cancer Vaccines

Related references

Note: Only part of the references are listed.
Article Gastroenterology & Hepatology

CDK1/2/5 inhibition overcomes IFNG-mediated adaptive immune resistance in pancreatic cancer

Jin Huang et al.

Summary: Inhibition of CDK1/2/5 kinase activity can overcome IFNG-mediated immune evasion in pancreatic tumors, turning a 'cold' tumor microenvironment into a 'hot' one and significantly improving overall survival rates in mouse pancreatic tumor models. Abnormal expression of CDK1/2/5 and IDO1 is associated with poor patient survival in various cancer types, including PDAC.
Review Oncology

Targeting immunogenic cancer cell death by photodynamic therapy: past, present and future

Razan Alzeibak et al.

Summary: The past decade has seen significant breakthroughs in cancer immunotherapy, with immunogenic cell death (ICD) emerging as a promising approach to eliminate tumor cells. Photodynamic therapy (PDT) can induce ICD, but its efficiency is reduced in hypoxic tumor environments. Future research may focus on strategies like oxygen-boosted PDT and nanotechnology to address this limitation.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2021)

Article Chemistry, Multidisciplinary

Reprogramming the Tumor Microenvironment through Second-Near-Infrared-Window Photothermal Genome Editing of PD-L1 Mediated by Supramolecular Gold Nanorods for Enhanced Cancer Immunotherapy

Honglin Tang et al.

Summary: The photothermal genome-editing strategy using a supramolecular cationic gold nanorod for CRISPR/Cas9 delivery to disrupt PD-L1 and induce immunogenic cell death (ICD) shows promising results in improving immune checkpoint blockade (ICB) therapy. This approach enhances dendritic cell conversion to T cells, promotes infiltration of cytotoxic T lymphocytes into tumors, and reprograms the immunosuppressive tumor microenvironment into an immunoactive one to inhibit primary and metastatic tumor activity with long-term immune memory effects.

ADVANCED MATERIALS (2021)

Article Biochemistry & Molecular Biology

Non-steroidal anti-inflammatory drugs induce immunogenic cell death in suppressing colorectal tumorigenesis

Rochelle Fletcher et al.

Summary: The study reveals that NSAIDs induce endoplasmic reticulum stress and activate BID protein to suppress tumor formation, and the immunogenic cell death effect induced by NSAIDs plays a crucial role in tumor suppression.

ONCOGENE (2021)

Article Oncology

Intratumoral virotherapy with 4-1BBL armed modified vaccinia Ankara eradicates solid tumors and promotes protective immune memory

Maria Hinterberger et al.

Summary: Intratumoral virotherapy with MVA-TAA-4-1BBL led to control of established tumors, triggering proinflammatory changes and immunogenic cell death in the tumor microenvironment. This approach induced reactivation and expansion of potent tumor-specific CD8(+) T cells, resulting in tumor elimination and protective immunological memory against tumor rechallenge.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2021)

Review Immunology

Necroptosis, pyroptosis and apoptosis: an intricate game of cell death

Damien Bertheloot et al.

Summary: Cell death is a fundamental physiological process in all living organisms, playing important roles in embryonic development, organ maintenance, aging, immune responses, and autoimmunity. Recent research has significantly increased our understanding of the mechanisms orchestrating different types of programmed cell death and how they affect the balance of cell fates. Various modalities of cell death, such as apoptosis, necroptosis, and pyroptosis, have been studied to highlight both common and unique pathways and their impact on the surrounding cells and the organism as a whole.

CELLULAR & MOLECULAR IMMUNOLOGY (2021)

Article Immunology

Personalized cancer vaccine strategy elicits polyfunctional T cells and demonstrates clinical benefits in ovarian cancer

Janos L. Tanyi et al.

Summary: By adding ASA and low-dose IL-2 to the OCDC-Bev-Cy combination regimen, we elicited vaccine-specific T-cell responses that positively correlated with prolonged time-to-progression and overall survival in patients. This combinatorial strategy was effective and demonstrated the utility of the ID8 ovarian model for future ovarian trial development.

NPJ VACCINES (2021)

Article Biotechnology & Applied Microbiology

Adenovirus and Oxaliplatin cooperate as agnostic sensitizers for immunogenic cell death in colorectal carcinoma

J. Milburn Jessup et al.

HUMAN VACCINES & IMMUNOTHERAPEUTICS (2020)

Review Immunology

Top 10 Challenges in Cancer Immunotherapy

Priti S. Hegde et al.

IMMUNITY (2020)

Article Chemistry, Multidisciplinary

Endoplasmic Reticulum Targeting to Amplify Immunogenic Cell Death for Cancer Immunotherapy

Hongzhang Deng et al.

NANO LETTERS (2020)

Article Medicine, General & Internal

Use of CAR-Transduced Natural Killer Cells in CD19-Positive Lymphoid Tumors

Enli Liu et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

Article Multidisciplinary Sciences

Intratumoral injection of the seasonal flu shot converts immunologically cold tumors to hot and serves as an immunotherapy for cancer

Jenna H. Newman et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

Review Oncology

Trial watch: chemotherapy-induced immunogenic cell death in immuno-oncology

Isaure Vanmeerbeek et al.

ONCOIMMUNOLOGY (2020)

Review Oncology

Consensus guidelines for the definition, detection and interpretation of immunogenic cell death

Lorenzo Galluzzi et al.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2020)

Article Biochemistry & Molecular Biology

Coupled scRNA-Seq and Intracellular Protein Activity Reveal an Immunosuppressive Role of TREM2 in Cancer

Yonatan Katzenelenbogen et al.

Article Biochemistry & Molecular Biology

TREM2 Modulation Remodels the Tumor Myeloid Landscape Enhancing Anti-PD-1 Immunotherapy

Martina Molgora et al.

Article Multidisciplinary Sciences

An RNA vaccine drives immunity in checkpoint-inhibitor-treated melanoma

Ugur Sahin et al.

NATURE (2020)

Review Biochemistry & Molecular Biology

The updated landscape of tumor microenvironment and drug repurposing

Ming-Zhu Jin et al.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2020)

Editorial Material Oncology

Crizotinib - a tyrosine kinase inhibitor that stimulates immunogenic cell death

Peng Liu et al.

ONCOIMMUNOLOGY (2019)

Article Multidisciplinary Sciences

Crizotinib-induced immunogenic cell death in non-small cell lung cancer

Peng Liu et al.

NATURE COMMUNICATIONS (2019)

Article Multidisciplinary Sciences

Neoantigen vaccine generates intratumoral T cell responses in phase Ib glioblastoma trial

Derin B. Keskin et al.

NATURE (2019)

Article Chemistry, Multidisciplinary

In Situ Dendritic Cell Vaccine for Effective Cancer Immunotherapy

Weijing Yang et al.

ACS NANO (2019)

Article Oncology

Immunogenic cell death induced by a new photodynamic therapy based on photosens and photodithazine

Victoria D. Turubanova et al.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2019)

Review Immunology

Cold Tumors: A Therapeutic Challenge for Immunotherapy

Paola Bonaventura et al.

FRONTIERS IN IMMUNOLOGY (2019)

Review Urology & Nephrology

Potentiating prostate cancer immunotherapy with oncolytic viruses

Patrick Lee et al.

NATURE REVIEWS UROLOGY (2018)

Review Biochemistry & Molecular Biology

A Paradigm Shift in Cancer Immunotherapy: From Enhancement to Normalization

Miguel F. Sanmamed et al.

Letter Medicine, General & Internal

Tumor Mutational Burden and Response Rate to PD-1 Inhibition

Mark Yarchoan et al.

NEW ENGLAND JOURNAL OF MEDICINE (2017)

Review Pharmacology & Pharmacy

Reprogramming of the Tumor in the Hypoxic Niche: The Emerging Concept and Associated Therapeutic Strategies

Guan-Zhong Qiu et al.

TRENDS IN PHARMACOLOGICAL SCIENCES (2017)

Article Biochemistry & Molecular Biology

The EGFR-specific antibody cetuximab combined with chemotherapy triggers immunogenic cell death

Chiara Pozzi et al.

NATURE MEDICINE (2016)

Review Biotechnology & Applied Microbiology

Oncolytic Newcastle disease virus as a prospective anti-cancer therapy. A biologic agent with potential to break therapy resistance

Volker Schirrmacher

EXPERT OPINION ON BIOLOGICAL THERAPY (2015)

Review Immunology

Immunogenic Cell Death in Cancer Therapy

Guido Kroemer et al.

ANNUAL REVIEW OF IMMUNOLOGY, VOL 31 (2013)

Article Biochemistry & Molecular Biology

Measles virus causes immunogenic cell death in human melanoma

O. G. Donnelly et al.

GENE THERAPY (2013)

Article Cell Biology

Cardiac Glycosides Exert Anticancer Effects by Inducing Immunogenic Cell Death

Laurie Menger et al.

SCIENCE TRANSLATIONAL MEDICINE (2012)

Article Oncology

Photodynamic Therapy of Cancer: An Update

Patrizia Agostinis et al.

CA-A CANCER JOURNAL FOR CLINICIANS (2011)

Article Medicine, General & Internal

Sipuleucel-T Immunotherapy for Castration-Resistant Prostate Cancer.

Philip W. Kantoff et al.

NEW ENGLAND JOURNAL OF MEDICINE (2010)

Article Biochemistry & Molecular Biology

Immunogenic death of colon cancer cells treated with oxaliplatin

A. Tesniere et al.

ONCOGENE (2010)

Review Oncology

Recent Advances in Cancer Vaccines: An Overview

Kyogo Itoh et al.

JAPANESE JOURNAL OF CLINICAL ONCOLOGY (2009)

Review Immunology

Immunogenic and tolerogenic cell death

Douglas R. Green et al.

NATURE REVIEWS IMMUNOLOGY (2009)

Letter Biochemistry & Molecular Biology

Calreticulin exposure is required for the immunogenicity of γ-irradiation and UVC light-induced apoptosis

M. Obeid et al.

CELL DEATH AND DIFFERENTIATION (2007)

Review Biochemistry & Molecular Biology

Pathogen recognition and innate immunity

S Akira et al.

Article Immunology

Caspase-dependent immunogenicity of doxorubicin-induced tumor cell death

N Casares et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2005)

Article Biochemistry & Molecular Biology

Cancer immunotherapy: moving beyond current vaccines

SA Rosenberg et al.

NATURE MEDICINE (2004)