BMP4 Moderates Glycolysis and Regulates Activation and Interferon-Gamma Production in CD4+T Cells

BMP4 is a key growth factor well known in promoting bone regeneration and has been reported to be able to regulate T cell development in the thymus. Here, we showed that BMP4 downregulates the activation of naive CD4+ T cells and the IFN-gamma production of CD4+ T cells without increasing regulatory T cells. BMP4 could also moderate glycolysis of T cells and regulate Hif1 alpha expression. Furthermore, BMP4 showed a suppressive function on the IFN-gamma production of CD4+ T cells in vivo. These findings indicating a mechanism by which BMP-4 may regulate activation and IFN-gamma production in CD4+ T cells via metabolism moderation and suggests that BMP4 may be a potential therapeutic supplement in autoinflammatory diseases.

Automated summary

The study indicates that BMP4 may regulate the activation and IFN-gamma production of CD4+ T cells through metabolism moderation, suggesting it could be a potential therapeutic supplement in autoinflammatory diseases.