Corneal Nerves, CD11c+ Dendritic Cells and Their Impact on Ocular Immune Privilege

The eye and the brain have limited capacities for regeneration and as such, immune-mediated inflammation can produce devastating consequences in the form of neurodegenerative diseases of the central nervous system or blindness as a result of ocular inflammatory diseases such as uveitis. Accordingly, both the eye and the brain are designed to limit immune responses and inflammation - a condition known as immune privilege. Immune privilege is sustained by physiological, anatomical, and regulatory processes that conspire to restrict both adaptive and innate immune responses.

Automated summary

The eye and the brain have limited regenerative capacities, making them vulnerable to immune-mediated inflammation. Immune privilege is a condition sustained by physiological, anatomical, and regulatory processes that restrict immune responses and inflammation in these organs.