Journal
FRONTIERS IN IMMUNOLOGY
Volume 12, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2021.701935
Keywords
contrasuppressor cells; nerves; dendritic cells; immune privilege; cornea
Categories
Funding
- Research to Prevent Blindness [P30-EY030413]
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The eye and the brain have limited regenerative capacities, making them vulnerable to immune-mediated inflammation. Immune privilege is a condition sustained by physiological, anatomical, and regulatory processes that restrict immune responses and inflammation in these organs.
The eye and the brain have limited capacities for regeneration and as such, immune-mediated inflammation can produce devastating consequences in the form of neurodegenerative diseases of the central nervous system or blindness as a result of ocular inflammatory diseases such as uveitis. Accordingly, both the eye and the brain are designed to limit immune responses and inflammation - a condition known as immune privilege. Immune privilege is sustained by physiological, anatomical, and regulatory processes that conspire to restrict both adaptive and innate immune responses.
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