The Macrophage Response Is Driven by Mesenchymal Stem Cell-Mediated Metabolic Reprogramming

Mesenchymal stem cells (MSCs) are multipotent adult stromal cells widely studied for their regenerative and immunomodulatory properties. They are capable of modulating macrophage plasticity depending on various microenvironmental signals. Current studies have shown that metabolic changes can also affect macrophage fate and function. Indeed, changes in the environment prompt phenotype change. Therefore, in this review, we will discuss how MSCs orchestrate macrophage's metabolic plasticity and the impact on their function. An improved understanding of the crosstalk between macrophages and MSCs will improve our knowledge of MSC's therapeutic potential in the context of inflammatory diseases, cancer, and tissue repair processes in which macrophages are pivotal.

Automated summary

MSCs, multipotent adult stromal cells, are widely studied for their regenerative and immunomodulatory properties, capable of modulating macrophage plasticity and function. Metabolic changes can also affect macrophage fate and function, prompting phenotype change in response to environmental cues. Understanding the crosstalk between macrophages and MSCs can improve therapeutic potential in inflammatory diseases, cancer, and tissue repair processes.