Journal
FRONTIERS IN IMMUNOLOGY
Volume 12, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2021.729336
Keywords
filamentous bacteriophage; glioma; target peptide; antibody; BBB; BBTB
Categories
Funding
- National Key R&D Program of China [2018YFC1311600]
- National Natural Science Foundation of China [81901880]
- Natural Science of Science and Technology Division Jilin [20200201505JC, 20190103099JH]
- Education department research project of Jilin [JJKH20201016KJ]
- program of Jilin finance department [2019SRCJ003]
- Jilin provincial health project [2020SC2T091]
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Glioma is a life-threatening malignant tumor with challenges in traditional treatments and drug delivery. Crossing the blood-brain barrier poses difficulties for drug vectors, but phage-based drugs offer advantages such as thermodynamic stability, biocompatibility, and low toxicity. Tumor-targeting peptides from phage library and phages displaying targeting peptides are ideal drug delivery agents for personalized treatment of glioma.
Glioma is a life-threatening malignant tumor. Resistance to traditional treatments and tumor recurrence present major challenges in treating and managing this disease, consequently, new therapeutic strategies must be developed. Crossing the blood-brain barrier (BBB) is another challenge for most drug vectors and therapy medications. Filamentous bacteriophage can enter the brain across the BBB. Compared to traditional drug vectors, phage-based drugs offer thermodynamic stability, biocompatibility, homogeneity, high carrying capacity, self-assembly, scalability, and low toxicity. Tumor-targeting peptides from phage library and phages displaying targeting peptides are ideal drug delivery agents. This review summarized recent studies on phage-based glioma therapy and shed light on the developing therapeutics phage in the personalized treatment of glioma.
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