Journal
ENVIRONMENTAL HEALTH AND PREVENTIVE MEDICINE
Volume 26, Issue 1, Pages -Publisher
SPRINGER
DOI: 10.1186/s12199-021-00982-w
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Funding
- Japan Society for the Promotion of Science [17H03740, 18K06448]
- Grants-in-Aid for Scientific Research [18K06448, 17H03740] Funding Source: KAKEN
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The study found a significant positive association between handgrip strength and hypertension in participants with high levels of CD34-positive cells, but not in those with low levels. This suggests that vascular homeostasis plays a role in maintaining muscle strength and its association with hypertension.
Background A positive association between handgrip strength and blood pressure has been reported. Since these factors are linked to the condition of the endothelium, the activity of endothelial repair might influence the association between handgrip strength and hypertension. Methods A cross-sectional study was conducted with 257 Japanese men aged 60-69 years who underwent an annual health checkup. As individuals with high level of circulating CD34-positive cells might show active endothelial repair, which plays an important role in vascular homeostasis, participants were stratified by circulating CD34-positive cell levels, using the median value of this population (0.96 cells/mu L) as the cutoff. Results Independent of known cardiovascular risk factors, for participants with a high CD34-positive cell, handgrip strength is significantly positively associated with hypertension (odds ratio and 95% confidence interval of hypertension for 1 standard deviation increment of handgrip strength were 1.85 (1.19, 2.88) but not for participants with a low CD34-positive cell (0.91 (0.61, 1.37)). Conclusion The positive association between handgrip strength and hypertension is limited to high CD34-positive cells. This result may help clarify the role of vascular homeostasis in maintaining muscle strength.
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