Synthesis and Structural Characterization of Isostructural 4-(4-Aryl)-2-(5-(4-fluorophenyl)-3-(1-(4-fluorophenyl)-5-methyl-1H-1,2,3-triazol-4-yl)-4,5-dihydro-1H-pyrazol-1-yl)thiazoles

4-(4-Chlorophenyl)-2-(5-(4-fluorophenyl)-3-(1-(4-fluorophenyl)-5-methyl-1H-1,2,3-triazol-4-yl)-4,5-dihydro-1H-pyrazol-1-yl)thiazole (4) and 4-(4-fluorophenyl)-2-(5-(4-fluorophenyl)-3-(1-(4-fluorophenyl)-5-methyl-1H-1,2,3-triazol-4-yl)-4,5-dihydro-1H-pyrazol-1-yl)thiazole (5) have been synthesized in high yields. Crystallization of 4 and 5 from dimethylformamide solvent produced samples suitable for structure determination by single crystal diffraction. The materials are isostructural with triclinic, PI and symmetry and comprise two independent molecules in the asymmetric unit. The two independent molecules in the asymmetric unit assume similar conformation. The molecule is essentially planar apart from one of the two fluorophenyl groups, which is oriented roughly perpendicular to the plane of the rest of the molecule.

Automated summary

The two target compounds have been successfully synthesized and crystallized from dimethylformamide solvent, producing suitable samples for structure determination. The materials are isostructural with triclinic symmetry and comprise two independent molecules in the asymmetric unit, which assume similar conformations. The molecule is essentially planar except for one fluorophenyl group, which is oriented roughly perpendicular to the rest of the molecule.