Journal
CRYSTALS
Volume 11, Issue 8, Pages -Publisher
MDPI
DOI: 10.3390/cryst11080948
Keywords
crystallization; RNA-protein complexes; spliceosome
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This review provides an overview of crystal structures solved by the Nagai group, which have advanced our understanding of the spliceosome mechanism by utilizing various strategies for crystal packing design.
Cryo-electron microscopy has greatly advanced our understanding of how the spliceosome cycles through different conformational states to conduct the chemical reactions that remove introns from pre-mRNA transcripts. The Cryo-EM structures were built upon decades of crystallographic studies of various spliceosomal RNA-protein complexes. In this review we give an overview of the crystal structures solved in the Nagai group, utilizing many of the strategies to design crystal packing as described in the accompanying paper.
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