Automatic Classification of A-Lines in Intravascular OCT Images Using Deep Learning and Estimation of Attenuation Coefficients

Intravascular Optical Coherence Tomography (IVOCT) images provide important insight into every aspect of atherosclerosis. Specifically, the extent of plaque and its type, which are indicative of the patient's condition, are better assessed by OCT images in comparison to other in vivo modalities. A large amount of imaging data per patient require automatic methods for rapid results. An effective step towards automatic plaque detection and plaque characterization is axial lines (A-lines) based classification into normal and various plaque types. In this work, a novel automatic method for A-line classification is proposed. The method employed convolutional neural networks (CNNs) for classification in its core and comprised the following pre-processing steps: arterial wall segmentation and an OCT-specific (depth-resolved) transformation and a post-processing step based on the majority of classifications. The important step was the OCT-specific transformation, which was based on the estimation of the attenuation coefficient in every pixel of the OCT image. The dataset used for training and testing consisted of 183 images from 33 patients. In these images, four different plaque types were delineated. The method was evaluated by cross-validation. The mean values of accuracy, sensitivity and specificity were 74.73%, 87.78%, and 61.45%, respectively, when classifying into plaque and normal A-lines. When plaque A-lines were classified into fibrolipidic and fibrocalcific, the overall accuracy was 83.47% for A-lines of OCT-specific transformed images and 74.94% for A-lines of original images. This large improvement in accuracy indicates the advantage of using attenuation coefficients when characterizing plaque types. The proposed automatic deep-learning pipeline constitutes a positive contribution to the accurate classification of A-lines in intravascular OCT images.

Automated summary

The study proposed a novel automatic method for A-line classification, utilizing convolutional neural networks (CNNs) for classification in its core and including arterial wall segmentation and an OCT-specific pre-processing step, as well as a post-processing step based on the majority of classifications. The OCT-specific transformation, based on estimation of the attenuation coefficient in every pixel of the OCT image, was identified as a critical step leading to improved accuracy in plaque type characterization.