4.6 Article

A Fast Ubiquitination of UHRF1 Oncogene Is a Unique Feature and a Common Mechanism of Thymoquinone in Cancer Cells

Related references

Note: Only part of the references are listed.
Article Oncology

Dihydroartemisinin induces cell apoptosis through repression of UHRF1 in prostate cancer cells

Tong Xia et al.

Summary: Dihydroartemisinin exhibits anti-proliferative and pro-apoptotic effects on prostate cancer cells by downregulating UHRF1 and upregulating p16(INK4A) expression.

ANTI-CANCER DRUGS (2022)

Review Genetics & Heredity

Thymoquinone Is a Multitarget Single Epidrug That Inhibits the UHRF1 Protein Complex

Omeima Abdullah et al.

Summary: The silencing of tumor suppressor genes through epigenetic mechanisms, mainly via abnormal promoter DNA methylation, is a main mechanism of tumorigenesis. UHRF1 plays a key role in this process as a conductor, and targeting UHRF1 is a promising strategy for cancer therapy. Thymoquinone (TQ) shows potential as a multitarget single epidrug that acts by targeting the UHRF1/DNMT1/HDAC1/G9a complex.

GENES (2021)

Review Pharmacology & Pharmacy

Recent Findings on Thymoquinone and Its Applications as a Nanocarrier for the Treatment of Cancer and Rheumatoid Arthritis

Ravi Raj Pal et al.

Summary: This study critically analyzes recent advancements in the delivery of thymoquinone for rheumatoid arthritis and cancer treatment, highlighting the potential of nanocarriers in enhancing drug internalization and efficacy against inflammation and cancer. Thymoquinone nanoparticles modulated autophagy and enhanced the potential of other drugs, while nanoformulations improved pharmacokinetics, drug deposition, and enhanced anti-inflammatory and anticancer properties through various delivery mechanisms. Metal toxicity reduction, clinical trials, and patents regarding thymoquinone were also discussed.

PHARMACEUTICS (2021)

Article Chemistry, Multidisciplinary

A Molecular Tool Targeting the Base-Flipping Activity of Human UHRF1

Liliyana Zaayter et al.

CHEMISTRY-A EUROPEAN JOURNAL (2019)

Article Cell Biology

Thymoquinone-induced antitumor and apoptosis in human lung adenocarcinoma cells

Saeed Samarghandian et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2019)

Article Medicine, Research & Experimental

LIN28B promotes the progression of colon cancer by increasing B-cell lymphoma 2 expression

Leilei Yuan et al.

BIOMEDICINE & PHARMACOTHERAPY (2018)

Article Biochemical Research Methods

Doxorubicin-induced DNA Damage Causes Extensive Ubiquitination of Ribosomal Proteins Associated with a Decrease in Protein Translation

Vincentius A. Halim et al.

MOLECULAR & CELLULAR PROTEOMICS (2018)

Review Pharmacology & Pharmacy

Enhanced efficacy and bioavailability of thymoquinone using nanoliposomal dosage form

M. R. Mohammadabadi et al.

JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY (2018)

Article Oncology

The Effect of Thymoquinone on Apoptosis of SK-OV-3 Ovarian Cancer Cell by Regulation of Bcl-2 and Bax

Xiaoli Liu et al.

INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER (2017)

Article Medicine, Research & Experimental

Promoter methylation-independent reactivation of PAX1 by curcumin and resveratrol is mediated by UHRF1

Gaurav Parashar et al.

CLINICAL AND EXPERIMENTAL MEDICINE (2016)

Review Oncology

Signalling pathways in UHRF1-dependent regulation of tumor suppressor genes in cancer

Mahmoud Alhosin et al.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2016)

Article Biochemistry & Molecular Biology

Shikonin causes apoptosis by up-regulating p73 and down-regulating ICBP90 in human cancer cells

Soon Young Jang et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2015)

Article Oncology

Luteolin Induces Apoptosis in BE Colorectal Cancer Cells by Downregulating Calpain, UHRF1, and DNMT1 Expressions

Mounira Krifa et al.

NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL (2014)

Article Biochemistry & Molecular Biology

Epigallocatechin-3-gallate up-regulates tumor suppressor gene expression via a reactive oxygen species-dependent down-regulation of UHRF1

Mayada Achour et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2013)

Article Pharmacology & Pharmacy

Increasing role of UHRF1 in the reading and inheritance of the epigenetic code as well as in tumorogenesis

Christian Bronner et al.

BIOCHEMICAL PHARMACOLOGY (2013)

Article Pharmacology & Pharmacy

Anisomycin suppresses Jurkat T cell growth by the cell cycle-regulating proteins

Chunyan Yu et al.

PHARMACOLOGICAL REPORTS (2013)

Article Biochemistry & Molecular Biology

Characterization of the protein ubiquitination response induced by Doxorubicin

Giorgia Mandili et al.

FEBS JOURNAL (2012)

Article Food Science & Technology

Anti-proliferative effect of curcumin on melanoma cells is mediated by PDE1A inhibition that regulates the epigenetic integrator UHRF1

Abdurazzag Abusnina et al.

MOLECULAR NUTRITION & FOOD RESEARCH (2011)

Article Biochemistry & Molecular Biology

The USP7/Dnmt1 complex stimulates the DNA methylation activity of Dnmt1 and regulates the stability of UHRF1

Max Felle et al.

NUCLEIC ACIDS RESEARCH (2011)

Article Biochemistry & Molecular Biology

Control of DNMT1 Abundance in Epigenetic Inheritance by Acetylation, Ubiquitylation, and the Histone Code

Christian Bronner

SCIENCE SIGNALING (2011)

Review Biochemistry & Molecular Biology

STAT3 as a target for cancer drug discovery

Luca Costantino et al.

CURRENT MEDICINAL CHEMISTRY (2008)

Article Biochemistry & Molecular Biology

ICBP90, a novel methyl K9H3 binding protein linking protein ubliquitination with heterochromatin formation

Panagiota Karagianni et al.

MOLECULAR AND CELLULAR BIOLOGY (2008)

Article Biochemistry & Molecular Biology

Deubiquitination of Chfr, a checkpoint protein, by USP7/HAUSP regulates its stability and activity

Young Mi Oh et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2007)

Article Biochemistry & Molecular Biology

Dinitrosyl-iron triggers apoptosis in Jurkat cells despite overexpression of Bcl-2

AL Kleschyov et al.

FREE RADICAL BIOLOGY AND MEDICINE (2006)

Article Biochemistry & Molecular Biology

Expression of cell survival/death genes: Bcl-2 and Bax at the rate of colon cancer prognosis

M Paul-Samojedny et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2005)

Article Biochemistry & Molecular Biology

A dynamic role of HAUSP in the p53-Mdm2 pathway

MY Li et al.

MOLECULAR CELL (2004)

Article Biochemistry & Molecular Biology

Np95 is a histone-binding protein endowed with ubiquitin ligase activity

E Citterio et al.

MOLECULAR AND CELLULAR BIOLOGY (2004)