Journal
APPLIED SCIENCES-BASEL
Volume 11, Issue 12, Pages -Publisher
MDPI
DOI: 10.3390/app11125742
Keywords
1; 2; 3-thiadiazole; synthetic strategies; biological activities; antiviral; anticancer; antifungal; insecticidal
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The 1,2,3-thiadiazole moiety is a significant player in the fields of medicine, pharmacology, and pharmaceutics due to its broad spectrum of biological activities. Various synthetic transformations and approaches have been highlighted in this review to showcase the diverse pharmaceutical and pharmacological activities of 1,2,3-thiadiazole scaffolds based on structure-activity relationship (SAR), attracting attention of researchers for potential therapeutic agents.
The 1,2,3-thiadiazole moiety occupies a significant and prominent position among privileged heterocyclic templates in the field of medicine, pharmacology and pharmaceutics due to its broad spectrum of biological activities. The 1,2,3-thiadiazole hybrid structures showed myriad biomedical activities such as antifungal, antiviral, insecticidal, antiamoebic, anticancer and plant activators, etc. In the present review, various synthetic transformations and approaches are highlighted to furnish 1,2,3-thiadiazole scaffolds along with different pharmaceutical and pharmacological activities by virtue of the presence of the 1,2,3-thiadiazole framework on the basis of structure-activity relationship (SAR). The discussion in this review article will attract the attention of synthetic and medicinal researchers to explore 1,2,3-thiadiazole structural motifs for future therapeutic agents.
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