Journal
APPLIED SCIENCES-BASEL
Volume 11, Issue 17, Pages -Publisher
MDPI
DOI: 10.3390/app11177994
Keywords
myocardial infarction; stroke; tocotrienols
Categories
Funding
- Universiti Kebangsaan Malaysia (UKM) [FF-2021-055]
Ask authors/readers for more resources
Tocotrienols have shown significant benefits in cerebral and myocardial I/R injury, improving structural, functional, and biochemical parameters while reducing oxidative stress, inflammation, and apoptosis. Differences in animal models, disease inductions, tocotrienol forms, and bias risks were limitations in the analysis, but tocotrienols have the potential to serve as a supplement for reducing the impact of reperfusion injury.
Although the current treatments for stroke and myocardial infarction contribute to an improvement in mortality rates, the consequences of reperfusion therapy have remained a challenge. Tocotrienols have been shown to exert beneficial effects on the brain and heart. This review aimed to determine the effects of tocotrienols in cerebral and myocardial ischemia-reperfusion (I/R) injury. We retrieved articles from Scopus, MEDLINE and PubMed from inception to June 2021, and included any studies using tocotrienols as a treatment for cerebral or myocardial I/R injury therapy. Observational studies and review articles were excluded, and the risk of bias was conducted using a specific tool for animal study (SYRCLE). The data were analyzed qualitatively. Twelve articles met the eligibility criteria. Tocotrienols significantly improved the structural, functional, and biochemical parameters in both cerebral and myocardial I/R injury models. In contrast, oxidative stress, inflammation, and apoptosis were markedly attenuated by tocotrienol treatment. Limitations to the analysis included marked differences in animal models, disease inductions, forms of tocotrienols, and an unclear risk of bias in certain types of bias. However, tocotrienols have the potential to serve as a supplement for reducing the impact of reperfusion injury.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available