Journal
ADVANCED SCIENCE
Volume 8, Issue 18, Pages -Publisher
WILEY
DOI: 10.1002/advs.202004721
Keywords
antibacterial activity; gene-targeted therapy; injectable hydrogel; intelligent release; photothermal therapy; uveal melanoma
Categories
Funding
- National Natural Science Foundation of China [U1932135, 81772875, 82073889, 81770961]
- Science and Technology Commission of Shanghai [20DZ2270800, 19JC1410200]
- S&T Innovation 2025 Major Special Program of Ningbo [2019B10063]
- Science and Technology Commission of Shanghai Municipality [19JC1415500, 20ZR1465000]
- National Science Fund for Distinguished Young Scholars of China [51525207]
- Ninth People's Hospital of Shanghai JiaoTong University School of Medicine
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An injectable and stimuli-responsive drug delivery antibacterial hydrogel (CP@Au@DC_AC50) has been successfully developed for uveal melanoma treatment, showing potential for clinical use with its gene-targeted therapy/PTT/antibacterial treatment pattern.
Uveal melanoma (UM) is the most prevalent primary intraocular malignant tumor with a high lethal rate. Patients who undergo conventional enucleation treatments consistently suffer permanent blindness, facial defects, and mental disorders, therefore, novel therapeutic modalities are urgently required. Herein, an injectable and stimuli-responsive drug delivery antibacterial hydrogel (CP@Au@DC_AC50) is constructed via a facile grinding method that is inspired by the preparation process of traditional Chinese medicine. The incorporation of gold nanorods can enhance the mechanical strength of the hydrogel and realize photothermal therapy (PTT) and thermosensitive gel-sol transformation to release the gene-targeted drug DC_AC50 on demand in response to low-density near-infrared (NIR) light. The orthotopic model of UM is built successfully and indicates the excellent efficiency of CP@Au@DC_AC50 in killing tumors without damage to normal tissue because of its synergistic mild temperature PTT and gene-targeted therapy. Moreover, the eyeball infection model reveals the remarkable antibacterial properties of the hydrogel which can prevent endophthalmitis in the eyeball. There is negligible difference between the CP@Au@DC_AC50+NIR group and normal group. This NIR light-triggered gene-targeted therapy/PTT/antibacterial treatment pattern provides a promising strategy for building multifunctional therapeutic platform against intraocular tumors and exhibits great potential for the clinical treatment of UM.
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