Journal
ADVANCED SCIENCE
Volume 8, Issue 16, Pages -Publisher
WILEY
DOI: 10.1002/advs.202100876
Keywords
combined therapy; drug delivery; liposomes; photodynamic therapy; theranostics
Categories
Funding
- National Key R&D Program of China [2020YFA0709900]
- Nanjing Tech University [38274017101, 3827401742]
- National Natural Science Foundation of China [22077101]
- Department of Science & Technology of Shaanxi Province [2020GXLH-Z-008]
- Northwestern Polytechnical University [2020GXLH-Z-008]
- Open Project Program of Wuhan National Laboratory for Optoelectronics [2020WNLOKF023]
- China-Sweden Joint Mobility Project [51811530018]
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This review discusses the development of liposomes as versatile nano-carriers for drug delivery in order to overcome limitations of PDT and enhance therapeutic effects.
Although photodynamic therapy (PDT) has promising advantages in almost non-invasion, low drug resistance, and low dark toxicity, it still suffers from limitations in the lipophilic nature of most photosensitizers (PSs), short half-life of PS in plasma, poor tissue penetration, and low tumor specificity. To overcome these limitations and enhance PDT, liposomes, as excellent multi-functional nano-carriers for drug delivery, have been extensively studied in multi-functional theranostics, including liposomal PS, targeted drug delivery, controllable drug release, image-guided therapy, and combined therapy. This review provides researchers with a useful reference in liposome-based drug delivery.
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