Journal
ACS INFECTIOUS DISEASES
Volume 7, Issue 8, Pages 2205-2208Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsinfecdis.1c00210
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Funding
- National Science Foundation [MCB1715494]
- AIChE Foundation
- Institute for Diabetes, Obesity, and Metabolism
- Penn Mental Health AIDS Research Center of the University of Pennsylvania
- Perelman School of Medicine at the University of Pennsylvania
- National Institute of General Medical Sciences of the National Institutes of Health [R35GM138201]
- Defense Threat Reduction Agency (DTRA) [HDTRA1-18-1-0041, HDTRA1-21-1-0014]
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Experts at IMAP and GRC conferences discussed the need for optimized and standardized test systems for novel antimicrobial peptides, and a survey was conducted to gather opinions on this topic. Based on the survey results, suggestions for future improvements in the research field were made.
The need for optimized as well as standardized test systems of novel antimicrobial peptides (AMPs) was discussed by experts in the field at the International Meeting on Antimicrobial Peptides (IMAP) 2017 and the 2019 Gordon Research Conference (GRC) on Antimicrobial Peptides, and a survey related to this topic was circulated to participants to collate opinions. The survey included questions ranging from the relevance of susceptibility testing for understanding the mode of action of AMPs, to the importance of optimization and a degree of standardization of test methods and their clinical relevance. Based on the survey results, suggestions for future improvements in the research field are made.
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