Journal
ACS BIOMATERIALS SCIENCE & ENGINEERING
Volume 7, Issue 9, Pages 4362-4370Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsbiomaterials.1c00549
Keywords
Hydrogel; wound repair; polymers; dressings; adhesion; degradation
Categories
Funding
- Boston Scientific Corporation
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This study reported the design, synthesis, and ex vivo evaluation of in situ polymerized hydrogels as colon wound dressings post polypectomy, with varied properties such as moduli, dissolution times, swelling, and adhesion to colon tissue. The hydrogels showed minimal cytotoxicity, prevented bacterial migration, exhibited rapid gelation, and have potential for application in colon endoscopy.
Currently, no dressings are utilized after removal of polyps during a colonoscopy rendering these tissue sites susceptible to bleeding, sepsis, and perfusion. We report the design specifications, synthesis, and ex vivo evaluation of in situ polymerized hydrogels as colon wound dressings post polypectomy. The hydrogels exhibited varied properties to include moduli between 100 and 16 000 Pa, dissolution times between 4 h to 7 days or longer, swelling up to 200%, and adhesion to colon tissue from 0.1 to 0.4 N/cm(2). The hydrogels displayed minimal cytotoxicity, prevented the migration/spread of bacteria, and exhibited rapid gelation, a requirement for application to the lumen of the colon via an endoscope. This work highlights the structure-property relationship of hydrogels prepared from N-hydroxysuccinimide functionalized PEG cross-linkers and hyperbranched polyethylenimines or 4-arm PEG-NH2 star polymers, and their potential as colon wound dressings.
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