Journal
ACS BIOMATERIALS SCIENCE & ENGINEERING
Volume 7, Issue 8, Pages 3594-3607Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsbiomaterials.1c00467
Keywords
Silk fibroin; Hydrogel; Absorbent; Hemostatic material; Xerogel
Categories
Funding
- National Natural Science Foundation of China [51973144]
- College Nature Science Research Project of Jiangsu Province, China [20KJA540002]
- PAPD
- Six Talent Peaks Project in Jiangsu Province [SWYY-038]
- European Union [668983-FoReCaST]
- FCT-Portugal project BREAST-IT [PTDC/BTM-ORG/28168/2017]
Ask authors/readers for more resources
In this study, a highly absorbent hydrogel was prepared using silk fibroin protein and riboflavin, with covalent bond crosslinking hindering the crystallization of the silk fibroin, resulting in an amorphous xerogel. This xerogel showed promising hemostatic properties and water absorption capacity, indicating its potential for rapid wound hemostasis and fluid absorption.
Highly absorbent polymers have a wide range of applications in biomaterials, agriculture, physiological products of daily uses, and others. Silk fibroin, as a natural biomaterial with excellent biocompatibility and tunable mechanical properties, shows good prospects in the field of biomedicine applications. However, the dried fibroin hydrogel has very low absorbency. In this work, silk fibroin protein is used as the carrier, riboflavin as the photosensitizer, and accordingly, the hydrogel is prepared by free radical cross-linking under ultraviolet light. The fibroin in the hydrogel contains mainly the random coil structure. The covalent bond crosslinking hinders the crystallization of the silk fibroin, thereby an amorphous silk fibroin hydrogel is obtained. After drying, this xerogel can absorb water 90 times more than its own mass and assimilates a good amount of water within a minute. In vitro and in vivo rabbit ear hemostasis experiments show that this fabricated xerogel has good hemostatic properties. Therefore, this xerogel exhibits good promise for rapid hemostasis of wounds and absorbing other body exudates.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available